mitoxantrone


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mitoxantrone

 [mi″to-zan´trōn]
a DNA-reactive agent of the anthracenedione group that inserts into DNA, causing crosslinks and strand breaks; administered intravenously as the hydrochloride salt as an antitumor antibiotic for the treatment of acute myelogenous leukemia and advanced, hormone-refractory prostate cancer. It is also used to reduce the frequency and severity of relapses in patients with secondary multiple sclerosis.

mitoxantrone

/mi·to·xan·trone/ (mi″to-zan´trōn) a DNA-intercalating anthracenedione, used as the hydrochloride salt as an antineoplastic agent in the treatment of acute myelogenous leukemia and advanced, hormone-refractory prostate cancer; also used in the treatment of secondary multiple sclerosis.

mitoxantrone

a synthetic antineoplastic antibiotic.
indications It is prescribed in combination with other approved drugs in the initial treatment of acute nonlymphocytic leukemia in adults and has activity against other leukemias, lymphoma, and breast cancer.
contraindications It should not be given to patients who are pregnant, have a clinically significant low left ventricular ejection fraction, or have evidence of prior hypersensitivity to this drug. Its use should be accompanied by close and frequent monitoring of hematologic and chemical laboratory parameters, as well as frequent patient observation.
adverse effects The side effects most often reported include hypotension, urticaria, dyspnea, rashes, phlebitis, myelosuppression, nausea, and vomiting.

mitoxantrone

Novantrone® Oncology A synthetic antitumor antibiotic Indications Combined with steroids, for treating hormone-refractory prostate CA, breast CA, AML and other lymphoproliferative malignancy and multiple sclerosis Pharmacokinetics Similar to doxorubicin Side effects Dose-limiting granulocytopenia, thrombocytopenia, N&V

mitoxantrone, mitozantrone

an anthracene derivative, similar to doxorubicin, used as an antineoplastic agent.
References in periodicals archive ?
CLAG-M is a salvage chemotherapy regimen consisting of cladribine, cytarabine, filgrastim and mitoxantrone that has become the standard of care at many institutions across the U.
Study TPI-ALV-201 is examining the efficiency of alvocidib, an investigational inhibitor of cyclin-dependent kinase 9 (CDK9), in combination with the authorized agents cytarabine and mitoxantrone in relapsed/refractory AML patients whose leukemia depends on MCL-1.
The phase 3 TROPIC study showed that cabazitaxel plus prednisone significantly improves OS in men with mCRPC who have previously been treated with a docetaxel-containing regimen compared with mitoxantrone plus prednisone.
The transporter inhibition potency of [beta]-carotene was evaluated by calcein-AM uptake assay and mitoxantrone accumulation assay.
Mitoxantrone is a drug used in the treatment of multiple sclerosis (MS), prostate cancer and leukemia.
GENOA, Italy, February 11, 2015--Stem cell transplants may be more effective than the drug mitoxantrone for people with severe cases of multiple sclerosis (MS), according to a new study.
Previous research into the issue showed that certain medications like interferon beta 1b (Betaseron), mitoxantrone (Novantrone)and natalizumab (Tysabri) can be used to treat patients with secondary progressive MS experiencing frequent attacks.
Mitoxantrone can be administered as an induction agent in fulminant aggressive MS attacks (see mitoxantrone therapy, section 6.
When the disease returned two years later, her parents enrolled her on a clinical trial in Glasgow for a treatment called mitoxantrone.
SUPERIOR TOPOISOMERASE II-INHIBITION BY DNA INTERCALATION WITH A MITOXANTRONE ANALOGUE.
In laboratory experiments, the THL successfully delivered the anti-cancer drug mitoxantrone (Novantrone), which is usually administered intravenously, to glioma and epithelial cancer cells.
A study showed that children whose acute lymphoblastic leukaemia (ALL) returns have a higher chance of survival if given the drug mitoxantrone.