mitoxantrone


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mitoxantrone

 [mi″to-zan´trōn]
a DNA-reactive agent of the anthracenedione group that inserts into DNA, causing crosslinks and strand breaks; administered intravenously as the hydrochloride salt as an antitumor antibiotic for the treatment of acute myelogenous leukemia and advanced, hormone-refractory prostate cancer. It is also used to reduce the frequency and severity of relapses in patients with secondary multiple sclerosis.

mitoxantrone

Novantrone® Oncology A synthetic antitumor antibiotic Indications Combined with steroids, for treating hormone-refractory prostate CA, breast CA, AML and other lymphoproliferative malignancy and multiple sclerosis Pharmacokinetics Similar to doxorubicin Side effects Dose-limiting granulocytopenia, thrombocytopenia, N&V
References in periodicals archive ?
* Since fingolimod and natalizumab will now be available, we recommend that mitoxantrone only be considered in the following situations:
The company said that the approval was based on the results of MCL-001, a phase II, multi-centre, single arm, open label study evaluating lenalidomide in 134 patients with MCL who had received prior treatment with rituximab, cyclophosphamide, an anthracycline (or mitoxantrone), and bortezomib alone or in combination.
These therapies may include natalizumab, cyclophosphamide, mitoxantrone, teri-flunomide, rituximab or fingolimod, among others.
Typical examples are the aromatic anthracycline antibiotics (daunomycin, doxorubicin, topotecan, mitoxantrone, etc.), which are effective against solid tumors and leukemia; quinolone antibiotics (norfloxacin, ofloxacin, etc.), exerting a wide spectrum of antibacterial activity; aromatic vitamins (riboflavin, nicotinamide, etc.), used as antioxidants in chemotherapy; methylxanthines which are present in high concentrations in food sources; and many other aromatic compounds, possessing useful medicobiological properties (Figure 1) [1,2].
The promising results have prompted the phase III study known as COMET-2 (CabOzantinib MET Inhibition CRPC Efficacy Trial) of cabozantinib versus mitoxantrone and prednisone to demonstrate a primary endpoint of pain reduction [ClinicalTrials.gov identifier: NCT01522443].
When the disease returned two years later, her parents enrolled her on a clinical trial in Glasgow for a treatment called mitoxantrone.
* Mitoxantrone (Novantrone) is a medication that has been approved by the FDA for SPMS, but some patients have experienced severe side effects, including leukemia, so treatment with this drug is limited to two to three years.
SUPERIOR TOPOISOMERASE II-INHIBITION BY DNA INTERCALATION WITH A MITOXANTRONE ANALOGUE.
The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone. Structure.
The immunosuppressive drugs include mitoxantrone (Novantrone), azathioprine (Imuran), methotrexate, cyclophosphamide (Cytoxan), or mycophenolate (CellCept).
Plasma exchange and Mitoxantrone are reportedly showed some promising options (9,10)
Se utilizan diferentes agentes antineoplasicos como Mitomicina C, Cisplatino, Carboplatino, Oxaliplatino, Paclitaxel, Docetaxel, Mitoxantrone, Doxorubicina y 5 Fluoracilo, que debido a la barrera peritoneo-plasmatica, permanecen largo tiempo dentro del abdomen antes de su absorcion y eliminacion, lo que los hace especialmente indicados en el tratamiento de la carcinomatosis peritoneal.