mitotic spindle


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spindle

 [spin´d'l]
1. a pin tapered at one end or both ends, or something with this shape.
2. the thin, tapering figure occurring during metaphase of cell division, composed of microtubules radiating from the centrioles and connecting to the chromosomes at their centromeres. Called also mitotic spindle.
3. muscle spindle.
mitotic spindle spindle (def. 2).
muscle spindle a mechanoreceptor found between the skeletal muscle fibers; the muscle spindles are arranged in parallel with muscle fibers, and respond to passive stretch of the muscle but cease to discharge if the muscle contracts isotonically, thus signaling muscle length. The muscle spindle is the receptor responsible for the stretch or myotatic reflex.
sleep s's bursts of activity of a particular waveform in the electroencephalogram in light or early sleep.

mi·tot·ic spin·dle

the fusiform figure characteristic of a dividing cell; it consists of microtubules (s. fibers), some of which become attached to each chromosome at its centromere and are involved in chromosomal movement; other microtubules (continuous fibers) pass from pole to pole.
Synonym(s): nuclear spindle

mi·tot·ic spin·dle

(mī-tot'ik spin'dĕl)
The fusiform figure characteristic of a dividing cell; it consists of microtubules (spindle fibers), some of which become attached to each chromosome at its centromere and appear to be involved in chromosomal movement; other microtubules (continuous fibers) pass from pole to pole.
Synonym(s): nuclear spindle.
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References in periodicals archive ?
None of the treatments combining Chocolate/Strawberry, Chocolate/ Condensed Milk and Strawberry/Condensed Milk induced significant number of abnormalities in the mitotic spindle and micronuclei, therefore were not genotoxic under the study conditions.
Toxicity in food flavorings at the cellular level associated with each other at different doses/Toxicidade em nivel celular de aromatizantes alimentares associados entre si em diferentes doses
STEWART: Yes, but the mitotic spindle is not involved in transcription.
Cellular basis of mechanotransduction
Many classical anti-cancer drugs act on the spindle microtubules: The taxanes originally obtained from the yew, for example, prevent the degradation of the microtubules and thus stabilize the mitotic spindle. As a result, the cancer cells remain stuck in cell division.
Germany : How resistance to important cancer drugs develops
merolae lacks a typical cytoskeleton, the tubulin function in this organism is mostly limited to the formation of mitotic spindles. (24, 29) Collectively, these results suggest that the dynamic changes in DYNAMO2 expression are similar to those in [alpha]-tubulin expression rather than Dnm1 expression, which mediates mitochondrial and peroxisomal fission supported by DYNAMO1 activity.
Dynamics of the nucleoside diphosphate kinase protein DYNAMO2 correlates with the changes in the global GTP level during the cell cycle of Cyanidioschyzon merolae
The alterations classified as aneugenic, related to malfunctioning of the mitotic spindle, including non-oriented chromosomes and c-metaphases (Leme & Marin-Morales, 2009), were the most frequent in previous studies carried out by Andrade-Vieira et al.
Cytogenetic bioassays as tools to distinguish between toxic and non-toxic varieties of Jatropha curcas (Euphorbiaceae)
(21) reported that the Nuclear-Mitotic Apparatus protein (NuMa-1) is responsible for organization of the mitotic spindle and the major target for mitotic apparatus antigens.
Evaluation of Rare Antinuclear Antibody Patterns in a Tertiary Hospital in Izmir
The large blastomere was the first to form the next mitotic spindle in the four--cell stage (Fig.
MEIOTIC AND EARLY ZYGOTIC DEVELOPMENT IN CRASSOSTREA VIRGINICA OBSERVED THROUGH CONFOCAL MICROSCOPY
(onion) is regarded in the scientific community as an effective bioassay for the assessment of acute toxicity at the cellular level of chemical compounds, due to low chromosome number (2n = 16), which facilitates the detection of chromosomal abnormalities and mitotic spindle changes (Neves, Ferreira, Lima, & Peron, 2014, Bianchi, Mantovani, & Marin-Morales, 2015).
Processed fruit juice ready to drink: screening acute toxicity at the cellular level/Sucos de frutas industrializados prontos para consumo: screening da toxicidade aguda em nivel celular
This organism has excellent kinetic properties of proliferation, large chromosomes in reduced number (2n = 16), which facilitates the detection of chromosomal aberrations and abnormalities in the mitotic spindle (Herrero et al., 2012; Cardoso et al., 2014).
Antiproliferative and genotoxic effects of nature identical and artificial synthetic food additives of aroma and flavor/Efeito antiproliferativo e genotoxico de aditivos alimentares de aroma e sabor sinteticos, dos tipos identico ao natural e artificial
Mitchison, "Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen," Science, vol.
Eg5 Overexpression Is Predictive of Poor Prognosis in Hepatocellular Carcinoma Patients
Many proteins take part in mitotic spindle reorientation during epidermal stratification by ACD.
Transit-Amplifying Cells in the Fast Lane from Stem Cells towards Differentiation
Moreover, dysregulated JNK activation, namely, p54 JNK inactivation and p46 JNK activation, and [p21.sup.WAF1] downregulation caused further checkpoint adaptation through defective maintenance of the G2/M and mitotic spindle checkpoints [5].
Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding

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