Nevertheless, the method of counting is subjective, time-consuming, and associated with problems of reproducibility in differentiating mitotic figures
from apoptotic cells, necrotic cells, or karyorrhexis, requiring experience of trained pathologists.
The International Endocervical Adenocarcinoma Criteria and Classification (IECC) (5) categorizes endocervical adenocarcinomas by the presence or absence of HPV infection-related features: easily identified apical mitotic figures
and apoptotic bodies.
Occasional mitotic figures
were seen, and background acellular, necrotic debris (Figure 4) was appreciated.
including the ones with peculiar starburst appearance were seen.
Thus, the first field counted might or might not contain a mitotic figure
. Fields were then counted systematically from left to right in descending rows using a manual mechanical stage.
(16) Cells in pseudotumoral deciduosis show less atypia and pleomorphism than does PMDM with no mitotic figures
. (1, 9) Expression of estrogen and progesterone receptors and [alpha]-inhibin by decidual cells in pseudotumoral deciduosis is also discriminative because those markers are negative in PMDM.
Although it had an MIB-1 proliferation index higher than 10% and some mitotic figures
, it was considered as benign because of the young of age of the patient and its superficial location.
The bland spindle cells usually show scant cytoplasm and occasionally mitotic figures
. In the infiltrates and scattered lymphocytes, germinal centers can often be identified.
Histologically, the specimen revealed a spindle cell neoplasm composed of interlacing fascicles; cellularity was high with only rare mitotic figures
. Immunohistochemical staining was focally reactive for both S-100 and SMA.
(7) defined the criteria for malignant glomus tumors as follows: deeply-located tumor, diameter >2 cm, presence of marked atypia along with atypical mitotic figures
, and mitotic activity.
The mitotic count was high, with up to 19 mitotic figures
per one X400 (high power) field.
are readily identified, greater than 5 per 10 high-power fields.