mitotic figure


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mi·tot·ic fig·ure

the microscopic appearance of a cell undergoing mitosis; a cell with the chromosomes that are visible by the light microscope.

mitotic figure

Etymology: Gk, mitos + L, figura, form
any chromosome or chromosome aggregation during any of the stages of mitosis.

mitotic figure

The corrugated blue-purple globule that corresponds to the mitotic spindle when examined by high-power light microscopy.

mi·tot·ic fig·ure

(mī-tot'ik fig'yŭr)
The microscopic appearance of a cell undergoing mitosis; a cell of which the chromosomes are visible by the light microscope.

mitotic

pertaining to mitosis.

mitotic activity
degree to which a cell population is proliferating; used as an index of tumor aggression. Can be quantified by counting the percentage of cells showing mitotic figures, or by flow cytometry.
mitotic figure
the condensed chromosomes by which a cell that is undergoing mitosis can be identified.
mitotic index
the percentage of cells simultaneously in the process of division, normally calculated after counting 1000 cells. Used in morbid pathology as a measure of the malignancy of a tumor, and in clinical pathology as an index of survival time of a neoplasm.
mitotic metaphase chromosomes
chromosomes in metaphase manifesting as mitotic figures.
mitotic nondisjunction
failure of proper disjunction of the paired chromosomes during metaphase which results in the chromosomal abnormalities of monosomy or trisomy.
mitotic potential
estimate of the cell's potential reproductive capacity.
References in periodicals archive ?
Nevertheless, the method of counting is subjective, time-consuming, and associated with problems of reproducibility in differentiating mitotic figures from apoptotic cells, necrotic cells, or karyorrhexis, requiring experience of trained pathologists.
Occasional mitotic figures were seen, and background acellular, necrotic debris (Figure 4) was appreciated.
Mitotic figures including the ones with peculiar starburst appearance were seen.
Microscopically tumor comprises of dense fascicles of spindle shaped cells exhibiting evident nuclear pleomorphism and mitotic figures.
Caption: Figure 2: (a) Cytology of the nodules showing anisokaryosis, hyperchromatic and stippled nuclei, prominent nucleoli, intranuclear inclusions, and pigment laden macrophages (H and E; x 100), (b) histopathology showing pleomorphic tumor cells with pleomorphic round to oval nuclei, prominent eosinophillic nucleoli, multinucleate giant cells with intracytoplasmic melanin pigment and atypical mitotic figures (H&E; X100).
At high-power magnification, they are composed of highly cellular spindle cell proliferations with uniform, elongated nuclei and rare mitotic figures.
WDSCC showed abundant intercellular bridging, cytoplasmic keratinisation and keratin pearls, nuclear pleomorphism was minimal and mitotic figures were <2/hpf.
Numerous keratin pearls and few mitotic figures with cellular and nuclear pleomorphism and hyperchromatism were also seen.
Histopathological examination revealed group of cells composed of haphazard arrangement of a mixture of large epithelioid, plasmacytoid and spindle cells with increased nuclear cytoplasmic ratio, nuclear pleomorphism and several mitotic figures (Figure 2).
The absence of tortuous, dilated blood vessels and mitotic figures supports the diagnosis of AGEP over plaque-type psoriasis.
Mitotic figures are rare, and there is no inflammatory infiltrate (CULEN & POPP, 2002).