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(mī-tot'ik), Avoid the jargonistic use of this word as a synonym of neoplastic or malignant.
Relating to or marked by mitosis.


Etymology: Gk, mitos, thread
pertaining to or characterized by mitosis, the process of cell division in the formation of identical daughter cells.


adjective Referring to mitosis.


Relating to or marked by mitosis.


(mi-to'sis) (mi-to'sez?) plural.mitoses [Gr. mitos, thread + -osis]
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A type of cell division of somatic cells in which each daughter cell contains the same number of chromosomes as the parent cell. Mitosis is the process by which the body grows and dead somatic cells are replaced. Mitosis is a continuous process divided into four phases: prophase, metaphase, anaphase, and telophase. mitotic (mi-tot'ik), adjective See: illustration; meiosis

Prophase: The chromatin granules of the nucleus stain more densely; the DNA strands coil extensively and become visible as chromosomes. These first appear as long filaments, each consisting of two identical chromatids, the result of DNA replication. Each pair of chromatids is joined at a region called the centromere, which may be central or toward one end. As prophase progresses, the chromosomes become shorter and more compact and stain densely. The nuclear membrane and the nucleoli disappear. At the same time, the centriole divides and the two daughter centrioles, each surrounded by a centrosphere, move to opposite poles of the cell. They are connected by fine protoplasmic fibrils, which form an achromatic spindle.

Metaphase: The chromosomes (paired chromatids) arrange themselves in an equatorial plane midway between the two centrioles.

Anaphase: The chromatids (now called daughter chromosomes) diverge and move toward their respective centrioles. The end of their migration marks the beginning of the next phase.

Telophase: The chromosomes at each pole of the spindle uncoil, the reverse of prophase, each becoming a long, loosely spiraled thread. The nuclear membrane re-forms and nucleoli reappear. Outlines of chromosomes disappear, and chromatin appears as granules scattered throughout the nucleus and connected by a lightly staining net. The cytoplasm divides (cytokinesis), resulting in two complete cells. This is accomplished in animal cells by constriction in the equatorial region; in plant cells, a cell plate develops in the same region and becomes the new cell wall. The period between two successive divisions is called interphase.

Mitosis is of particular significance in that genes are distributed equally to each daughter cell, and the diploid number of chromosomes is maintained in all somatic cells of an organism.

heterotypic mitosis

The first or reduction division in the maturation of germ cells.

homeotypic mitosis

The second or equational division in the maturation of germ cells.


pertaining to mitosis.

mitotic activity
degree to which a cell population is proliferating; used as an index of tumor aggression. Can be quantified by counting the percentage of cells showing mitotic figures, or by flow cytometry.
mitotic figure
the condensed chromosomes by which a cell that is undergoing mitosis can be identified.
mitotic index
the percentage of cells simultaneously in the process of division, normally calculated after counting 1000 cells. Used in morbid pathology as a measure of the malignancy of a tumor, and in clinical pathology as an index of survival time of a neoplasm.
mitotic metaphase chromosomes
chromosomes in metaphase manifesting as mitotic figures.
mitotic nondisjunction
failure of proper disjunction of the paired chromosomes during metaphase which results in the chromosomal abnormalities of monosomy or trisomy.
mitotic potential
estimate of the cell's potential reproductive capacity.
References in periodicals archive ?
Disruption of cell division is usually caused by a primary effect on the mitotic apparatus (Hess, 1983).
Grade 2: tumours have some fibrillary matrix, moderate nuclear pleomorphism and some mitotic activity.
In our study none of the 12 cases with both a negative progesterone receptor result, as determined by immunohistochemistry, and a mitotic count score greater than 1 had a low Recurrence Score; thus, our results support the importance of the proliferation gene group and hormone receptor gene group in the determination of the Recurrence Score.
Indeed, the cytoplasmic motor protein dynein, a protein involved in the movement of chromosomes and positioning the mitotic spindles for cell division, is an early target for destruction during apoptosis (Karp, 2005).
An earlier version of the guideline, published in 2010, had called for upgrading thin (less than 1 mm), nonulcerated melanomas with a mitotic rate (MR) of at least 1/[mm.
Conclusion: In addition to histopathological findings (tumor size and mean mitotic count), diffuse p16 expression and p53 overexpression can be used to distinguish between benign and malignant USMTs.
Lactuca sativa roots treated with distilled water showed the highest mitotic indices, differing statistically from roots subjected to methanol and hexane extracts with 50, 100, and 200 [micro]g [mL.
Table 1 presents the number of cells in interphase and at different stages of cell division, and the values of mitotic index obtained from meristematic cells of A cepa roots treated with water and food flavorings of Passion Fruit and Vanilla.
When 3T3-L1 preadipocyte cells are induced to differentiate, the cells are known to undergo several rounds of mitosis referred to as mitotic clonal expansion.
So, aqueous extract of Thyme was found to be most effective against cells that were multiplying rapidly and created cytotoxic effect either by blocking the formation of the mitotic spindle in M-phase or by damaging the DNA during the S-phase of the cell cycle.
They then tested whether these micro-RNAs could also influence the orientation of mitotic spindles in developing mouse brains.