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a cytotoxic compound that causes severe damage to the adrenal cortex; administered orally as an antineoplastic agent for palliative treatment of inoperable adrenocortical carcinoma.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Lysodren® Oncology A cytotoxic agent that controls the endocrine Sx in Pts with adrenocortical CA and ACTH producing pituitary tumors that cause Cushing's disease Adverse effects Anorexia, N&V, neurologic disturbances–ataxia, speech defects, somnolence, vertigo, lethargy, liver enzyme changes–↑ ALA, ALT, alkaline phosphatase, GGT, ↑ corticosteroid-binding globulin, ↑ sex hormone-binding globulin, ↑ cholesterol, ↓ uric acid, ↓ thyroid hormones–normal TSH. See Adrenocortical carcinoma.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

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References in periodicals archive ?
Mitotane, selegiline, and trilostane are the drugs used.
After HAC initial treatment with mitotane (Lisodren[R], Bristol-Myers, Brazil) and subsequent insulin dose adjustments the tutors agreed on an exploratory laparotomy.
(5) The most commonly used chemotherapeutic, and the only Federal Drug Agency (FDA) and Health Canada approved agent is mitotane, with response rates ranging from approximately 10-30% in both single and multi-chemotherapy regimens.
Qiu, "Sunitinib monotherapy instead of mitotane combination therapy for the treatment of refractory adrenocortical carcinoma," International Journal of Urology, vol.
These medications that accelerate hepatic glucocorticoid metabolism include rifampicin, mitotane, anticonvulsants such as phenytoin, carbamazepine, oxcarbazepine, phenobarbital, and topiramate.
Other case reports have described usage of metyrapone, etomidate, mitotane, and mifepristone as steroidogenesis inhibitors [8].
Ketoconazole, metyrapone, etomidate, mitotane, and mifepristone can be used to reduce the circulating cortisol level.
We excluded studies to assess the therapeutic use of o,p'-DDD iso-form, commercially known as mitotane or lysodren.
oral Mitotane (actividad citotoxica Dolor gastrointestinal, a nivel de la corteza ginecomastia, hepatotoxicidad, suprarrenal) 3-5 g por dia hipercolesterolemia, Insuficiencia orales suprarrenal y neurotoxicidad.