Munoz, "The NK-1 receptor is expressed in human primary gastric and colon adenocarcinomas and is involved in the antitumor action of L-733,060 and the mitogenic
action of substance P on human gastrointestinal cancer cell lines," Tumour Biology, vol.
Auxiliary mitogens, such as bile acids (BAs) , norepinephrine (NE) , endothelial growth factor (VEGF) , insulin-like growth factor system (IGF system) , estrogen , and serotonin  (Table 1), although not mitogenic
in cultured hepatocytes, may delay liver regeneration in their absence.
In theory, they may trigger imbalanced mitogenic
effects compared to native insulin [109, 111].
The lectin isolated from another edible mushroom Pleurotus citrinopileatus showed in vitro mitogenic
activity on mouse splenocytes, with the maximal stimulation at 2 [micro]M of lectin concentration .
Responsiveness to a mitogenic
lectin, phytoheamagglutinin-P was significantly reduced in Group A as compared to Group B, followed by Group C.
In these studies, the lectin from Artocarpus heterophyllus is considered to be mitogenic
for human [CD4.sup.+] T cells , whereas Artocarpus lakoocha has antiproliferative effect on human leukemic cells , and Dolichos biflorus agglutinin is used to isolate leukemic T cells .
Being regarded as a new mitogenic
peptide for endothelial cells (12), apelin can promote cells from [G.sub.0]/[G.sub.1] to S phase and stimulate epithelial proliferation.
The E5 protein of bovine papilloma virus coupled with platelet derived growth factor-[beta] causes the activation of latter and results in a sustained mitogenic
Also, lymphocyte proliferative response to mitogenic
stimulation was increased after the race.
In human T lymphocytes, voltage-gated [K.sup.+] channels are crucial to transmembrane potential and cell proliferation in response to mitogenic
stimulation [15, 16].
Recent evidence suggests that testosterone may induce differentiation and cell cycle arrest in prostate cancer (in contrast to the mitogenic
effect of DHT).[sup.14] Consequently, a 5ARI that raises testosterone and reduces levels of nuclear DHT could provide a useful adjunct to IAD.
Urso et al., "Role of the time factor in signaling specificity: application to mitogenic
and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases," Metabolism, vol.