mitogen-activated protein kinase

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MAP kinase

Any of a family of serine/threonine protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group, which are involved in cellular responses to various stimuli (e.g., mitogens, osmotic stress, heat shock and cytokines) and regulate cell growth, cycling, differentiation, mitosis and apoptosis.

mitogen-activated protein kinase



A signaling protein, i.e., a protein that circulates extracellularly influencing other cells to turn on the process of protein synthesis. These proteins have an effect on cellular replication and cellular death in inflammatory, ischemic, and malignant diseases.

mitogen-activated protein kinase

Abbreviation: MAPK
A signaling enzyme, i.e., one that circulates extracellularly, influencing cells to begin protein manufacturing. They affect cellular replication and death in inflammatory, ischemic, and malignant diseases.
See also: protein kinase
References in periodicals archive ?
Suppression of UVB-induced phosphorylation of mitogen-activated protein kinases and nuclear factor kappa B by green tea polyphenol in SKH-1 hairless mice.
IL-31 acts through three singling pathways: JAK/STAT pathway (Janus-activated kinase/signal transducer and activator of transcription), PI3K/AKT (phosphatidylinositol 3 -kinase/protein kinase) pathway, and MAPK (mitogen-activated protein kinase) pathway [12].
Firestein, "The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis," Annals of the Rheumatic Diseases, vol.
Clerk, "'Stress-responsive' mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium," Circulation Research, vol.
Omura et al., "Activation of mitogen-activated protein kinases and activator protein-1 in myocardial infarction in rats," Cardiovascular Research, vol.
Lee, "Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase," Journal of Biological Chemistry, vol.
Involvement of p38 mitogen-activated protein kinase signaling pathway in osteodastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL).J.
Vernay et al., "An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development," EMBO Reports, vol.
The anti-Akt (pan) (40D4) monoclonal antibody (mAb), anti-phospho-Akt ([Ser.sup.473]) polyclonal antibody (pAb), antiphospho-(Ser) protein kinase C (PKC) substrate pAb, antiphospho-p38 mitogen-activated protein kinase (MAPK) ([Thr.sup.180]/[Tyr.sup.182]) pAb, anti-p38 MAPK (5F11) mAb, antiphospho-p44/42 MAPK (ERK1/2) ([Thr.sup.202]/[Tyr.sup.204]) pAb, antip44/42 MAPK (137F5) mAb, anti-phospho-c-Jun N-terminal kinse (JNK) ([Thr.sup.183]/[Tyr.sup.185]) mAb, and anti-JNK pAb were purchased from Cell Signaling (Beverly, MA).
Zhao et al., "Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38S," The Journal of Biological Chemistry, vol.
Mitogen-activated protein kinases (MAPKs) are a group of intracellular serine/threonine protein kinases.

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