MAPK pathway

(redirected from mitogen-activated protein kinase pathway)

MAPK pathway

Mitogen-activated protein kinase pathway. An evolutionarily conserved cascade in which three families of protein kinases act in sequence to effect cell responses to various stimuli. An activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. ERK MAPKs are activated by mitogenic stimulation; CSBP2 and JNK MAPKs are activated by environmental stress (e.g., osmotic shock, UV irradiation), wound stress and inflammatory factors.
References in periodicals archive ?
MEK inhibitors target the mitogen-activated protein kinase pathway. Trametinib has been approved for treating advanced melanoma, and more than a dozen other MEK inhibitors are in clinical trials (including selumetinib and cobimetinib) for the treatment of melanoma and other solid-organ malignant neoplasms, including pancreatic, hepatocellular, colorectal, and non-small cell lung cancer, the authors noted.
Singh, "p38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against [beta]-adrenergic receptor-stimulated apoptosis.
Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide.
Otterbein et al., "Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3," The Journal of Biological Chemistry, vol.
Guh et al., "The p38 mitogen-activated protein kinase pathway plays a critical role in PAR2-induced endothelial IL-8 production and leukocyte adhesion," Shock, vol.
Ifedigbo et al., "MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury," American Journal of Pathology, vol.
Activation of the p42 mitogen-activated protein kinase pathway inhibits Cdc2 activation and entry into M-phase in cycling Xenopus egg extracts.
Genomewide RNAi screen identifies protein kinase Cb and new members of mitogen-activated protein kinase pathway as regulators of melanoma cell growth and metastasis.
Correia Freitas et al., "The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription," Biological Chemistry, vol.
Chiou et al., "Fenofibrate suppresses melanogenesis in B16-F10 melanoma cells via activation ofthe p38 mitogen-activated protein kinase pathway," Chemico-Biological Interactions, vol.
Rawadi, "A Mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF-[kappa]B activity and cytokine secretion in macrophages via the activation of mitogen-activated protein kinase pathways," The Journal of Biological Chemistry, vol.

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