MAP3K12(redirected from mitogen-activated protein kinase kinase kinase 12)
MAP3K12An oncogene on chromosome 12q13 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K12 may activate the JNK/SAPK pathway; it is highly expressed in brain and kidney.
Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.