MAP3K1(redirected from mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein)
MAP3K1A gene on chromosome 5q11.2 that encodes a MAPK kinase kinase belonging to the signal transduction cascades. MAP3K1 regulates the ERK and JNK kinase pathways, as well as the NF-kappaB pathway. MAP3K1 is activated by autophosphorylation.
Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
Pathology MAP3K1 defects cause sex reversal type 6.
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