(redirected from mitogen-activated protein kinase kinase kinase 1)


A gene on chromosome 5q11.2 that encodes a MAPK kinase kinase belonging to the signal transduction cascades. MAP3K1 regulates the ERK and JNK kinase pathways, as well as the NF-kappaB pathway. MAP3K1 is activated by autophosphorylation. 

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.

Pathology MAP3K1 defects cause sex reversal type 6.
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References in periodicals archive ?
MEKK1, mitogen-activated protein kinase kinase kinase 1; PKC, protein kinase C; NIK, NF-[kappa]B inducing kinase; NEDD8, neural precursor cell expressed developmentally downregulated 8.
The three polymorphisms used in the study were rs2981582 in FGFR-2 (fibroblast growth factor receptor type 2), rs3803662 near TNRC9 (trinucleotide repeat containing 9), and rs889312 near MAPKKK1 (mitogen-activated protein kinase kinase kinase 1).

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