mitogen-activated protein kinase


Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.
Related to mitogen-activated protein kinase: MAP kinase, MAPK

MAP kinase

Any of a family of serine/threonine protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group, which are involved in cellular responses to various stimuli (e.g., mitogens, osmotic stress, heat shock and cytokines) and regulate cell growth, cycling, differentiation, mitosis and apoptosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

mitogen-activated protein kinase

,

MAPK

A signaling protein, i.e., a protein that circulates extracellularly influencing other cells to turn on the process of protein synthesis. These proteins have an effect on cellular replication and cellular death in inflammatory, ischemic, and malignant diseases.

mitogen-activated protein kinase

Abbreviation: MAPK
A signaling enzyme, i.e., one that circulates extracellularly, influencing cells to begin protein manufacturing. They affect cellular replication and death in inflammatory, ischemic, and malignant diseases.
See also: protein kinase
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Pae, "Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways?" Journal of Signal Transduction, vol.
Differential activation of mitogen-activated protein kinases in experimental mesangioproliferative glomerulonephritis.
Oestrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells.
Activation of mitogen-activated protein kinases (Erk1 and Erk2) cascade results in phosphorylation of NF-M tail domains in transfected NIH 3T3 cells.
Davis, "Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways," Journal of Molecular Medicine, vol.
Strniskova, "Mitogen-activated protein kinase: a new therapeutic target in cardiac pathology," Molecular and Cellular Biochemistry, vol.
Yamaguchi, "Acidic pH stimulates the production of the angiogenic CXC chemokine, CXCL8 (interleukin-8), in human adult mesenchymal stem cells via the extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and NF-[kappa]B pathways," Journal of Cellular Biochemistry, vol.
Research continues to elucidate new pathological mechanisms and develop new oral agents including Janus kinase (Jak), protein kinase C (PKC), and mitogen-activated protein kinase (MAPK) inhibitors (Figure 2).
In which, KRAS, as one of the mitogen-activated protein kinase (MAPK) signaling pathways, the RAS-RAF-MEK-ERK signaling pathway is a key pathway in many signaling pathways that control cell growth, proliferation, differentiation and apoptosis.
Glucocorticoid receptor (GR) and mitogen-activated protein kinase phosphatase 1 (MKP-1) expression were detected by polymerase chain reaction and Western blotting (WB).
Extracellular signal-regulated kinase 5 (Erk5), which is a member of the mitogen-activated protein kinase (MAPK) family, is phosphorylated by MAPK/Erk kinase-5 (Mek5) to regulate the function of various cell types.

Full browser ?