mitogen


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Related to mitogen: Pokeweed mitogen

mitogen

 [mi´to-jen]
a substance that induces blast transformation; DNA, RNA, and protein synthesis; and proliferation of lymphocytes; e.g., concanavalin A, phytohemagglutinin, or lipopolysaccharide.

mi·to·gen

(mī'tō-jen),
A substance frequently derived from plants that stimulates mitosis and lymphocyte transformation in an antigen-nonspecific manner; includes not only lectins such as phytohemagglutinins, pokeweed mitogen, and concanavalin A, but also substances from streptococci (associated with streptolysin S) and from strains of α-toxin-producing staphylococci.
Synonym(s): transforming agent (1)
[mitosis + G. -gen, producing]

mitogen

(mī′tə-jən)
n.
An agent that induces mitosis.

mi′to·gen′ic (mī′tə-jĕn′ĭk, mĭt′ə-) adj.
mi′to·ge·nic′i·ty (-jə-nĭs′ĭ-tē) n.

mi·to·gen

(mī'tō-jen)
A substance that stimulates mitosis and lymphocyte transformation; includes not only lectins such as phytohemagglutinins and concanavalin A, but also substances from streptococci (associated with streptolysin S) and from strains of α-toxin-producing staphylococci.

mitogen

1. Any agent that promotes cell nuclear division (MITOSIS). Mitogens are important in genetic research and technology. Pokeweed mitogen, derived from the plant Phytolacca americana , is a powerful mitogen of B LYMPHOCYTES.
2. Any substance that non-specifically causes lymphocytes to proliferate.

mitogen

a growth factor in the form of a small protein found in blood serum that often has a specific target organ in which it induces MITOSIS.

mi·to·gen

(mī'tō-jen)
A substance that stimulates mitosis and lymphocyte transformation; includes not only lectins such as phytohemagglutinins and concanavalin A, but also substances from streptococci and from strains of α-toxin-producing staphylococci.
References in periodicals archive ?
Effect of application of PSM isolated from Astragalus corniculatus on the mitogen responsibility of the spleen lymphocytes in hamsters with progressing Graffi myeloid tumors were followed during 21 days after tumor transplantation.
In this study, we used the MTT assay to detect the proliferation activity of splenocytes after T-lymphocyte (PHA, 10 [micro]g/ml) and B-lymphocyte mitogen (LPS, 50 [micro]g/ml) stimulation.
As shown in our results, most of the extracts exerted inhibitory effect on tumor cells and/or mitogen activated normal spleen cells growth ([IC.sub.50] 1-85 [mu]g/ml).
In addition our results showed that AgC (17.5 ng/mL) can inhibit the production of IL-2 induced by mitogens. Hence, the immunosuppression induced in PBMC could be mediated by the inhibition of IL-2 release.
Unstimulated and/or PHA and PWM mitogen stimulated cell cultures were prepared as described above.
The report provides comprehensive information on the Hepatocyte Growth Factor (Hepatopoietin-A or Lung Fibroblast Derived Mitogen) , targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
PPRV infects PBMCs of goat: In order to evaluate ability of Vero cell adapted Nigeria 75/1 strain of PPRV to infect lymphocytes of naAve goats in vitro PBMCs with or without mitogen stimulation were put in contact with PPRV.
Zhang, "Evolutionary history of the vertebrate mitogen activated protein kinases family," PLoS ONE, vol.
Briefly, aliquots of the PBMCs ([10.sup.5]/well) were seeded in triplicate wells of 96-well plates and stimulated for 6 days individually with the mitogens concanavalin-A (Con A), phytohemagglutinin (PHA), and pokeweed mitogen (PWM) (each at 5 [micro]g/mL final concentration) (Sigma, St Louis.
(5, 6) It is also a potent mitogen for normal and neoplastic tissues, and it may be involved in growth dysregulation and carcinogenesis.
After 30 min of preincubation with compounds, PBMC were stimulated or not with 10 pg/ml of mitogen PHA.

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