Additionally, the dynamin-related GTPase mitofusin
2 (Mfn2) proteins located on the ER intermingle with Mfn1 or Mfn2 on mitochondria to tighten the connection.
Moreover, observed upregulation of mir-140, which exerts effect on mitochondrial fission and apoptosis through targeting mitofusin
1 (Mfn1), may be directly correlated with frequently observed in [ASC.sub.EMS] mitochondrial fission.
Zorzano, "Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptory coactivator-1[alpha], estrogen-related receptor-[alpha], and mitofusin
2," Diabetes, vol.
In yeast, Fzo1 (Mitofusin
ortholog) degradation is mediated by the 26S proteasome .
1/2 (Mfn1/2) and optic atrophy1 (Opa1) are known to induce mitochondrial fusion [44, 45], while dynamin-related protein 1 (Drp1) is identified to interact with fission protein 1 (Fis1) to promote mitochondrial fission [46, 47].
Liesa et al., "Role of mitofusin
2 in the renal stress response," PLoS ONE, vol.
In animal models, mitofusin
2 (Mfn2) plays a key role in mitochondrial muscle damage control, since in the aging process there is a progressive Mfn2 reduction in the skeletal muscle of the mice, besides, the Mfn2 ablation produces a gene mark of aging.
Hypoxia leads to upregulation of mitofusin
1 (MFN1), a mitochondrial fusion protein, both in vivo and in vitro.
MiR-106a promotes cardiac hypertrophy by targeting mitofusin
Fission and fusion mitochondrial dynamics are controlled by groups of dynamins: GTPases [60, 73] among them standout DRP-1 (dynamin-related protein 1), Mfn (Mitofusin
), and OPA (optic atrophy protein-1) .
1 and mitofusin
2 are ubiquitinated in a PINK1/Parkin-dependent manner upon induction of mitophagy," Human Molecular Genetics, vol.
Kang, "Stimulator of IFN genes-mediated DNA-sensing pathway is suppressed by NLRP3 agonists and regulated by mitofusin
1 and TBC1D15, mitochondrial dynamics mediators," The FASEB Journal, vol.