mitochondrial proton leak

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mitochondrial proton leak

A physiologic process in which oxidative phosphorylation is uncoupled from ATP synthesis with energy dissipated as heat. Protons re-enter the mitochondrial matrix through facilitated diffusion mediated by uncoupling protein-1 (UCP1; thermogenin) without contributing to ATP synthesis.
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References in periodicals archive ?
Feeding conditions and breed affect the level of DNA methylation of the mitochondrial uncoupling protein 3 gene in chicken breast muscle.
Addition of the mitochondrial uncoupling agent, dinitrophenol, was found to modulate the [Ca.sup.2+] content and production of free radicals in the mitochondria of penumbra [Korde et.
Changes in mitochondrial uncoupling protein expression in the rat vestibular nerve after labyrinthectomy.
Mitochondrial uncoupling proteins in the CNS: in support of function and survival.
CoQ10 is also involved in the prevention of mitochondrial ROS formation as an obligatory cofactor for mitochondrial uncoupling proteins [13, 14].
Mitochondrial uncoupling also dissipates [DELTA]p, but by allowing translocation of [H.sup.+] into the matrix independent of ATP synthase.
Abel, "Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes," Physiology (Bethesda), vol.
Esteves, "Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3," Cell Metabolism, vol.
The Mitochondrial Uncoupling Mechanisms of Crustaceans and Other Marine Invertebrates
St-Pierre et al., "Superoxide activates mitochondrial uncoupling proteins," Nature, vol.
Carvalho et al., "Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection," Journal ofBioenergetics and Biomembranes, vol.

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