A remarkable finding is that RSH and SIH seem to differently affect mitochondrial respiration
of PBMCs, whereas platelet respiration remained unchanged.
CoQ10 supplementation induced an increase in mitochondrial respiration
(Figure 3 (a)) and also increased almost all key respiratory parameters, while there was no effect of CoQ10 carrier control (Figure 3(b)).
These effects were prevented by inhibition of complex II with 3-nitropropionic acid or malonate, indicating that BHB primarily influences mitochondrial respiration
at complex II , which is consistent with ketolysis increasing formation of succinate and [FADH.sub.2].
Adaptive thermogenesis is a component of energy expenditure whereby mammals generate heat through the uncoupling of mitochondrial respiration
in brown adipose tissue (BAT) .
Patino et al., "p53 regulates mitochondrial respiration
," Science, vol.
Currently, the state-of-the-art seahorse flux analyzer platform, developed by Agilent, is equipped to perform highly accurate real-time measurement of extracellular acidification (ECAR) and oxidative phosphorylation (OCR) as surrogate measures of cellular glycolysis and mitochondrial respiration
This study highlights especially the transition from hepatic specification to hepatic maturation as dependent on mitochondrial respiration
. Together, this will help elucidating the role of mitochondria in the regulation of stem cells and progeria.
Experimental findings suggest that prolonged and unopposed inflammatory processes during sepsis amplify TNF[alpha] production, whose catabolic effects on murine skeletal muscle trigger both decreased mitochondrial respiration
and impaired biogenesis (through PGC-1[alpha] inactivation ).
The metabolic reprogramming from mitochondrial respiration
(Q-HSCs) to glycolysis (A-HSCs) is thought to require hedgehog (Hh) signaling, because cyclopamine, which blocks hedgehog signaling by binding to Smoothened (Smo), inhibited the accumulation of the PKM2-positive cells generated when liver repair is provoked by acute partial hepatectomy.
Enhanced heme function and mitochondrial respiration
promote the progression of lung cancer cells.
Nitric oxide increases mitochondrial respiration
in a cGMP-dependent manner in the callus from Arabidopsis thaliana.
In this organ the uncoupling protein 1 (UCP1) is expressed, and this protein is involved in the generation of heat through uncoupled mitochondrial respiration
from ATP synthesis, and this is the reason that it is considered as a thermogenic organ.