mitochondrial proton leak

mitochondrial proton leak

A physiologic process in which oxidative phosphorylation is uncoupled from ATP synthesis with energy dissipated as heat. Protons re-enter the mitochondrial matrix through facilitated diffusion mediated by uncoupling protein-1 (UCP1; thermogenin) without contributing to ATP synthesis.
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References in periodicals archive ?
Gallyas Jr., "Lipophilic Triphenylphosphonium Cations Inhibit Mitochondrial Electron Transport Chain and Induce Mitochondrial Proton Leak," PLoS ONE, vol.
The mechanisms that regulate mitochondrial proton leak are induced by FA [28].
Brand, "The regulation and physiology of mitochondrial proton leak," Physiology Journal, vol.
Porter, "Mitochondrial proton leak: a role for uncoupling proteins 2 and 3," Biochimica et Biophysica Acta, vol.
The objective of this research is to evaluate liver mitochondrial respiration from progeny of two Angus bulls with high and low RFI to examine the association between RFI, liver mitochondrial respiration rates, and liver mitochondrial proton leak kinetics.
But, since no differences were found in liver mitochondrial respiration rates at State 3 and State 4 or in RCR values, the higher gain per kg of DMI of low RFI steers was not associated with a decrease in liver mitochondrial proton leak or the capacity for liver mitochondrial respiration.
Mitochondrial proton leak is a process that dissipates proton motive force through the movement of protons across the mitochondrial inner membrane without production of ATP [18].
It was expected that differences in RFI between Angus steers were correlated with hepatic mitochondrial proton leak because proton leak is a major contributor to mitochondrial efficiency and resting energy expenditure [5, 6].
Pehowich, "Thyroid hormone status and membrane n3 fatty acid content influence mitochondrial proton leak," Biochimica et Biophysica Acta, vol.
Brookes, "Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection," The Biochemical Journal, vol.
Jarmuszkiewicz, "Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak," PLoS ONE, vol.
Harper, "Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production," The American Journal of Physiology: Endocrinology and Metabolism, vol.

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