MICU1

(redirected from mitochondrial calcium uptake 1)

MICU1

A gene on chromosome 10q22.1 that encodes a key regulator of mitochondrial calcium uptake, which is required for calcium entry into mitochondria. MICU1 may act as a calcium sensor via its EF-hand domains, gating the calcium channel partner activity. MICU1 induces T-helper-1-mediated autoreactivity, which is accompanied by release of IFNG.
References in periodicals archive ?
MICU1, mitochondrial calcium uptake 1; MICU2, mitochondrial calcium uptake 2; MCUR1, mitochondrial calcium uniporter regulator 1; EMRE, essential mitochondrial calcium uniporter regulator.
HajnEczky and his team revealed the function of MICU1 (Mitochondrial Calcium Uptake 1).
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