mithramycin


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plicamycin

 [pli″kah-mi´sin]
an antineoplastic antibiotic produced by Streptomyces plicatus that binds to DNA and inhibits RNA synthesis; it is used for treatment of advanced testicular carcinoma; major side effects are thrombocytopenia and hemorrhagic diathesis that can be life-threatening. It also has an inhibiting effect on osteoclasts and is used to treat hypercalcemia and hypercalciuria caused by metastatic malignancy. Administered intravenously. Formerly called mithramycin.

mith·ra·my·cin

(mith'ră-mī'sin),
An antibiotic produced by Streptomyces argillaceus and S. tanashiensis; possesses antineoplastic activity.

mithramycin

A drug that reduces bone metabolism and can be useful in the treatment of PAGET'S DISEASE and HYPERCALCAEMIA.

mith·ra·my·cin

(mith'ră-mī'sin)
An antibiotic produced by Streptomyces argillaceus and S. tanashiensis; possesses antineoplastic activity.
References in periodicals archive ?
Cho, "Mithramycin A inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of Bax and oligomerization," Molecular Pharmacology, vol.
Rutigliano et al., "The DNA-binding drugs mithramycin and chromomycin are powerful inducers of erythroid differentiation of human K562 cells," British Journal of Haematology, vol.
Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis.
(11) One case report associated acquired dysfibrinogenemia with mithramycin administration.
Endosperm nuclei (a combination of three endosperms per petri dish) were stained with mithramycin A (a GC-binding DNA fluorochrome; Sigma, St.
Mithramycin and 4[prime]-6-diamidino-2-phenylindole (DAPI)-DNA staining for fluorescence microspectrophotometric measurement of DNA in nuclei, plastids, and virus particles.
Tobey, "Effects of cytosine arabinoside, daunomycin, mithramycin, azacytidine, adriamycin, and camptothecin on mammalian cell cycle traverse," Cancer Research, vol.