misoprostol


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Related to misoprostol: Mifepristone

misoprostol

 [mi″so-pros´tol]
a synthetic prostaglandin E1 analogue used to treat gastric irritation resulting from long-term therapy with nonsteroidal antiinflammatory drugs. It is also used in conjunction with mifepristone for termination of pregnancy in the first trimester. Administered orally.

misoprostol

Apo-Misoprostol (CA), Cytotec, Novo-Misoprostol (CA), PMS-Misoprostol (CA)

Pharmacologic class: Prostaglandin E1 analog

Therapeutic class: Antiulcerative, cytoprotective agent

Pregnancy risk category X

FDA Box Warning

• In pregnant women, drug can cause abortion, premature birth, or birth defects. Uterine rupture has occurred when drug was given to pregnant women to induce labor or to induce abortion beyond week 8 of pregnancy.

• Don't give to pregnant women to reduce risk of nonsteroidal anti-inflammatory drug (NSAID)-induced ulcers.

• Advise patients of drug's abortifacient property and warn them not to give it to others.

• Don't use drug to reduce risk of NSAID-induced ulcers in women of childbearing potential unless patient is at high risk for complications from gastric ulcers linked to NSAIDs or at high risk for gastric ulcers. In such patients, drug may be prescribed if patient has had negative serum pregnancy test within 2 weeks before starting therapy; is able to comply with effective contraceptive measures; has received both oral and written warnings of drug's hazards, risk of possible contraception failure, and danger to other women of childbearing potential should drug be taken by mistake; and will begin drug only on second or third day of next normal menstrual period.

Action

Reduces gastric acid secretion and increases gastric mucus and bicarbonate production, creating a protective coating on gastric mucosa

Availability

Tablets: 100 mcg, 200 mcg

Indications and dosages

To prevent gastric ulcers caused by NSAIDs

Adults: 200 mcg q.i.d. with food, with last daily dose given at bedtime. If intolerance occurs, decrease to 100 mcg q.i.d.

Off-label uses

• Duodenal ulcer

• Pregnancy termination

Contraindications

• Prostaglandin hypersensitivity

• Pregnancy

Precautions

Use cautiously in:

• females of childbearing age

• breastfeeding patients

• children younger than age 18 (safety not established).

Administration

Before starting therapy, make sure female patient understands dangers of taking drug while pregnant or breastfeeding.

• Be aware that drug should not be used in females of childbearing age, except those who need NSAIDs and are at high risk for complications from NSAID-associated gastric ulcers.

• For antiulcer use in females, start therapy on day 2 or 3 of normal menses.

Adverse reactions

CNS: headache

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence

GU: miscarriage, menstrual disorders, postmenopausal bleeding

Interactions

Drug-drug. Magnesium-containing antacids: increased risk of diarrhea

Patient monitoring

• Assess GI status. Report significant adverse reactions.

• Monitor menstrual pattern or postmenopausal bleeding. Report significant problems.

Patient teaching

• Instruct patient to take with food.

• Advise patient to report diarrhea, abdominal pain, and menstrual irregularities.

Tell patient drug may cause spontaneous abortion. Stress importance of using reliable contraception.

• Instruct female patient using drug for ulcer treatment to start therapy on second or third day of normal menses.

• Caution patient not to take magnesium-containing antacids, which may worsen diarrhea.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

mi·so·pros·tol

(mī'sō-prost'ol),
A prostaglandin analogue used for prevention of gastric and duodenal ulcers; particularly useful in patients taking nonsteroidal antiinflammatory drugs; antiulcerative. A component of the mifepristone-regimen for early termination of pregnancy.

misoprostol

(mī′sō-prŏs′tôl′, -tōl′, -tŏl′)
n.
An oral prostaglandin analog, C22H38O5, that stimulates the production of gastric mucus and is used to prevent and treat gastric ulcers, especially in patients using NSAIDs. It is also used to induce labor and in conjunction with the drug RU 486 to induce abortion in early pregnancy.

misoprostol

A synthetic PGE1 analogue administered vaginally with mifepristone (RU 486) as an abortifacient. It is also used to prevent NSAID-induced gastric ulcers and in patients with a history of GI bleeding. Misoprostol may be of use in reducing acute rejection of renal allografts, a phenomenon partially due to ischaemic damage of kidneys that occurs between the time of “harvesting” and re-establishment of the blood flow; misoprostol-treated group subjects suffered acute rejection one-half as often as the placebo group.

When compared to PGE2, misoprostol induces complete abortion (i.e., passage of foetus and placenta simultaneously) more often (43% vs 32% for PGE2), was more convenient (insertion of two 100-µg tablets at 12 hours vs insertion of 20 mg suppository every 3 hours, plus antidiarrhoeal, antiemetic and antipyretic medication required for PGE2 therapy), was associated with fewer side effects, including fever (11% vs 63%), vomiting (4% vs 33%) and diarrhoea (4% vs 30%), and is less expensive (USD $0.97 vs $315.30).

misoprostol

Obstetrics A synthetic PGE1 analogue administered vaginally with mifepristone–RU 486 as an abortifacient, also used to manage peptic and duodenal ulcers. See Abortion, Gemeprost, Mifepristone, Sulprostone.

mi·so·pros·tol

(mī'sō-prost'ol)
1. Prostaglandin analogue used to prevent gastric and duodenal ulcers.
2. A component of the mifepristone-regimen for early termination of pregnancy.

misoprostol

A PROSTAGLANDIN drug used to treat peptic ulcers especially those caused by NON-STEROIDAL ANTI-INFLAMMATORY DRUGS. Brand names are Cytotec and Mifegyne. The drug is also formulated with DICLOFENAC under the brand name Arthrotec, and with NAPROXEN under the brand name Napratec, for the treatment of RHEUMATOID ARTHRITIS.

mi·so·pros·tol

(mī'sō-prost'ol)
A prostaglandin analogue used to prevent gastric and duodenal ulcers; particularly useful in patients taking nonsteroidal antiinflammatory drugs.
References in periodicals archive ?
A comparison of vaginal versus buccal misoprostol for cervical ripening in women for labor induction at term (the IMPROVE trial): a triple masked randomized controlled trial.
Misoprostol, a prostaglandin E1 analog is the most commonly used agent for medical termination of pregnancy.
concluded that although vaginal and surgical evacuation was more effective than Misoprostol in solving the problem, still medical treatment is effective and acceptable especially when surgical management is not available or risky or patients refuse to undergo surgical management (9).
But misoprostol (Cytotec) alone for women with a closed cervical os can require a second dose or intervention.
Findings from a trial show that while the standard drug regimen using misoprostol on its own frequently fails to complete the miscarriage, a combination of misoprostol and the drug mifepristone works better.During miscarriage, if the body does not expel the pregnancy tissue on its own, which is the final part of a miscarriage, women need to undergo a surgical procedure or take the drug misoprostol.
The researchers found that 83.8 percent of 148 women in the mifepristone-pretreatment group and 67.1 percent of 149 women in the misoprostol-alone group had complete expulsion after one dose of misoprostol (relative risk, 1.25).
The current study was done with the objective of comparing the efficacy, acceptability and safety of low-dose oral misoprostol tablet (25 ugm PGE1) and intracervical dinoprostone (PGE2) for labour induction and cervical ripening in women at term.
The aim of this prospective study was to assess the efficacies of laminaria, vaginal misoprostol, and mechanical dilator applications before surgical intervention with regard to the optimal cervical dilation and severity of pain in first-trimester pregnant women with missed abortion.
Misoprostol is the only prostaglandin [E.sub.1] analogue uterine stimulant that is currently commercially available in obstetrics and gynaecology; all other prostaglandin preparations, commercially known as Prostin, Prandin, Prepidil, and by many other names, are prostaglandin [E.sub.2] analogues, and long preceded the use of misoprostol.
From 124 women, 62 were managed by up to two doses of 800-ug misoprostol intra-vaginally and 62 expectantly.
A total of 12 patients who received misoprostol had complete healing at 8 weeks, compared with 4 in the placebo group (P= .017).
Misoprostol is a prostaglandin E1 methyl ester and is used orally for the prevention or treatment of peptic ulcer.