mismatch repair gene

mismatch repair gene

Any of a number of genes (e.g., MLH1, PMS1, MSH2, etc.) which encode an enzyme that scans newly replicated DNA for errors and repairs mismatched bases in the DNA. Defects in mismatch repair genes result in replication errors and genetic instability. Germ-line mutations are associated with hereditary cancer syndromes—e.g., hereditary nonpolyposis colorectal cancer.
References in periodicals archive ?
Surveillance colonoscopy improves survival in a cohort of subjects with a single mismatch repair gene mutation.
Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumours from HNPCC patients.
The loss of mismatch repair gene proteins in colorectal carcinoma is one such example.
Analysis of mismatch repair gene mutations in Tureish HNPCC patients.
DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer.
Black patients more frequently showed loss of expression of the mismatch repair gene proteins hMLH1 (23%; 29/128) (p=0.
This study supports earlier reports of alterations in mismatch repair gene expression for sebaceous neoplasms in patients with MTS (9, 14-23) and brings evidence in favor of immunohistochemical analysis as a practical first-line screening test.
Cancer risk associated with germline DNA mismatch repair gene mutations.
Mismatch repair gene analysis in Catalonian families with colorectal cancer.
Mismatch repair gene defects are associated with microsatellite instability, which may be associated with a predisposition to cancer.