PMS2

(redirected from mismatch repair endonuclease PMS2)

PMS2

A gene on 7p22.2 that encodes a mismatch repair enzyme that scans newly replicated DNA for errors and repairs mismatched bases in the DNA. The enzyme forms a heterodimer with MLH1, and this complex interacts with other complexes bound to mismatched bases.

Molecular pathology
Defects in PMS2 cause hereditary nonpolyposis colorectal cancer type 4, Turcot syndrome and supratentorial primitive neuroectodermal tumours.
References in periodicals archive ?
coli) (MLH1), (4) DNA mismatch repair protein Msh2 (MSH2), mutS homolog 6 (MSH6), mismatch repair endonuclease PMS2 (PMS2), and epithelial cell adhesion molecule (EPCAM), such as occurs in patients with Lynch syndrome, for whom more than 90% of colon cancers test MSI positive (1, 2).
coli); MSH2, DNA mismatch repair protein Msh2; MSH6, mutS homolog 6; PMS2, Mismatch repair endonuclease PMS2; EPCAM, epithelial cell adhesion molecule.