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mis-sense mutationa change to the base sequence of a DNA CODON so that it now encodes a different amino acid. For example, a SUBSTITUTION MUTATION in the first base of a triplet might produce the following missense mutation: CCU (pro) → ACU (thr). see GENETIC CODE.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005