DYRK1B

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DYRK1B

A gene on chromosome 19q12-q13.1 that encodes a dual-specificity kinase with both serine/threonine and tyrosine kinase activities. DYRK1B enhances transcriptional activity of TCF1/HNF1A and FOXO1 and inhibits epithelial cell migration; it mediates colon carcinoma cell survival in mitogen-poor environments.
References in periodicals archive ?
In Mirk's The Festial ghosts visit the living to tell them of the pains of purgatory, and demonic voices call out to the people they haunt in Mather's Remarkable Providences (1684).
The material bread remains only in appearance; Christ appears "in forme of bredde." As Lasynas initial doubt is grounded in her material production of the bread, Mirk's narrative undoes the value of Lasynas labor: it cannot serve adequately as the basis for understanding the nature of the consecrated bread.
BMC XI succinctly explains why the nomenclature "Printer of Mirk" is used in preference to "Rood:"
Mirk took on this story because "media about Guantanamo focuses almost exclusively on policy discussions and the opinions of high-ranking decision-makers." As a result, human impacts as well as the experiences of those working at the facility are "overshadowed."
Chronicler John Mirk of Lilleshall Abbey in Shropshire wrote in the 15th century that midsummer partying had fallen into "lechery and gluttony turning the good, holy devotion into sin."
She examines the short sequence of Marian exempla in Mirk's Festial, in particular texts which highlight the difference between the old and new law through the difference between physical letters and meaning.
Pencampwr Treialon Rhyngwladol 2012 oedd Ian Brownlie gyda Boredale Guss o'r Alban; yn ail, bachgen ifanc o'r enw Robert Ellis a Mirk o Bort Talbot; gyda'r cystadleuydd ifancaf, Fraser Shennan o'r Alban gyda Fuzz yn drydydd.
His score of 60 Merit points and 537 Judges' points put him well ahead of Welshman Robert Ellis and Mirk, of Nantymoel, Bridgend, who had been in the lead.
As the Princess was arriving at the farm, Robert Ellis and his dog Mirk, six, from Nantymoel, were competing in the showground.
Mirk Ray, a teacher librarian and intructional technology facilitator, as chosen as the 2012 Washington State Teacher of the Year.
MIRK TIME: Phil Jones clashes with Montenegro star Mirko Vucinic
Mercury blogger Sarah Mirk summed it up with this headline: "Attention!