MIR23B

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MIR23B

A gene on chromosome 9q22.32 that encodes an RNA gene.
References in periodicals archive ?
Mir-23b and miR-130b expression is downregulated in pituitary adenomas.
Xue, "Long non-coding RNA TUSC7, a target of miR-23b, plays tumor-suppressing roles in human gliomas," Frontiers in Cellular Neuroscience, vol.
In particular, downregulation of miR-148b and miR-4269 and upregulation of miR-23b and miR-4429 were reported in obese visceral adipocyte EVs.
The proinflammatory cytokine IL-17 can facilitate the progress of inflammatory autoimmune diseases, which leads to downregulation of miR-23b in human FLS [31].
Another miRNA that is involved with chondrocyte proliferation is miR-23b, which regulates the mRNA that encodes a cAMP-dependent protein kinase, essential for cell proliferation.
miR-3074 is a less investigated member of miR-23b cluster that its dysregulation has been reported in various cancers (30-34).
Likewise, miR-23b associated with advanced stage (p = 0.021) and B-symptoms (p = 0.025).
miRNA tailing byTUT4 and TUT7, regulation by BCDIN3D (BCDIN3 domain containing RNA methyltransfease), RNA editing by ADAR1, a reduction in RNA stability controlled by MCPIP1 (MCP-induced protein 1), and IRE1[alpha] (Ser/Thr protein kinase/endoribonuclease) regulate Dicer processing of let-7, miR-145, miR-23b, miR-146a, miR-135b, miR-17, miR-34a, miR-96, miR-125b, and miR-151 respectively.
It is predicted that miR-23b can target the conservative sequence of EV713' UTR by biological software.
found that miR-23b overexpression inhibited radiation-induced autophagy and sensitized PDAC cells to radiation.
showed that miR-21, miR-222, miR-23b, miR-24, and miR-27a are upregulated in monocyte differentiation and miR-29 in monocyte infection which suggests that these miRNAs may regulate monocyte defence mechanisms through TGF-[beta] signalling [142].
There have been reports that miR-23b levels were increased in the kidneys of TGF-[beta]1 transgenic mice and rats following subtotal nephrectomy, which was found to be localized to podocytes and tubular epithelium by in situ hybridization.