Minus strand | definition of minus strand by Medical dictionary
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rep·li·ca·tive form (RF),
1. an intermediate stage in the replication of either DNA or RNA viral genomes that is usually double stranded;
2. the altered, double-stranded form to which single-stranded coliphage DNA is converted after infection of a susceptible bacterium, formation of the complementary ("minus") strand being mediated by enzymes that were present in the bacterium before entrance of the viral ("plus") strand.
minus strand A segment of DNA—produced by a single-stranded DNA virus infecting a eukaryotic host cell—which is complementary or antiparallel to the first strand. When such segments are derived from the virus itself, they are termed “plus” strands.
References in periodicals archive
The claims also cover siRNAs targeting the plus and the minus strands
of the virus and the genes encoded by the viral genome.