Polymorphous low-grade adenocarcinoma occurs almost exclusively in the minor salivary glands
and may contain overlapping histopathologic features with ACC such as ductal, tubular, and even cribriform growth.
It has been recommended that MRI be performed for all tumors that demonstrate malignant cytology, for all deep-lobe parotid lesions, and for sublingual and minor salivary gland
tumors (because of their high likelihood of malignancy).
Pleomorphic adenomas of the minor salivary glands
are typically not encapsulated, but they are usually well circumscribed and lack a truly infiltrative growth.
While it is an uncommon tumor, it accounts for about 25% of all intraoral minor salivary gland
The squamous metaplasia of minor salivary gland
ducts and acini may contain apoptotic cells and areas of inflammation as well as mucin spillage.
Clear cell tumors of minor salivary gland
origin: an immunohistochemical and ultrastructural analysis.
Large studies of salivary gland tumors found that between 64 and 80% of all primary epithelial salivary gland tumors occurred in the parotid gland, 7 to 11% in the submandibular gland, fewer than 1% in the sublingual gland, and 9 to 23% in the minor salivary glands
However, adenosquamous carcinoma has been reported as a minor salivary gland
tumor with distinct histologic foci of both squamous and glandular differentiation.
Tumors of all histologies were included, but tumors of the minor salivary glands
were not included in this study because of limitations imposed by the ICD-O system.
Forty-nine cases of benign and malignant salivary gland tumors involving both major and minor salivary glands
were selected from the surgical pathology files (recorded between 1987 and 1999) at the University of Pennsylvania Medical Center, Philadelphia, Pa.
A rare case of sclerosing mucoepidermoid carcinoma arising in minor salivary glands
with immunohistochemical evaluation.
26] Studies are needed to characterize the histologic and temporal salivary gland changes that involve the ducts, acini, or matrix constituents in both the major and minor salivary glands
of HIV-infected patients.