minor cluster region

minor cluster region

A 500-bp region of DNA located 20–30 kb in the 3’ direction from the major breakpoint region (MBR), where 20–30% of the t(14:18) translocations occur (seen in most follicular lymphomas). MBR can be identified by polymerase chain reaction (PCR).
References in periodicals archive ?
Additional breakpoints are described in 30 kb 3' of the MBR in the minor cluster region (mcr).
(10.) Ngan BY, Nourse J, Cleary ML: Detection of chromosomal translocation t(14;18) within the minor cluster region of bc1-2 by polymerase chain reaction and direct genomic sequencing of the enzimatically amplified DNA in follicular lymphomas.
Abdou MT, Hegyi 1, Dours-Zimmermann MT, Kurrer MO, Heitz PU, Zimmermann DR: High fregeuency of t(14;18) translocation breakpoints outside of major breakpoint and minor cluster regions in follicular lypmhomas: Improved polymerase chain reaction protocols for their detection.