Launched to dermatologists in July 2006 after approval by FDA on May 8, 2006, SOLODYN is the only branded oral minocycline
approved for once daily dosage in the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 12 years of age and older.
The hyperpigmentation of minocycline
is classified into 4 different types, based on clinical features, light and electron microscopy, and energy dispersive X-ray analysis:
Cutaneous Reaction Patterns to Drugs Clinical Pattern Selected Drug Examples Acneiform lithium, corticosteroids, androgens Lichenoid thiazides, antimalarials, captopril Fixed drug eruption tetracyclines, sulfonamides, barbiturates Morbilliform beta-lactam antibiotics, calcium channel blockers Urticarial beta-lactam antibiotics, aspirin Pityriasis rosea-like captopril, gold Pigmentation minocycline
, antimalarials, bleomycin Subacute lupus-like hydrochlorothiazide, terbinafine Systemic lupus-like procainamide, hydralazine, minocycline
Serum sickness-like cefaclor, minocycline
Pemphigus-like captopril, penicillamine Pseudoporphyria naproxen, furosemide Photosensitivity doxycycline, thiazides, sulfonylureas Source: Dr.
is a tetracycline antibiotic that is commonly used in the initial treatment of moderate to severe acne and is typically taken once or twice daily with food (Garner et al.
BPX-011 is a hydrophilic (non-oil-based) topical gel with fully solubilized minocycline
that has been shown to penetrate the skin to deliver the antibiotic to its target.
Two hours after ischemia induction (counted after the removal of the cannula), animals received saline or minocycline
intraperitoneally (four doses of 50 mg/kg every 12 hours followed by five doses of 25 mg/kg every 24 hours).
After 6 months of this therapy, his BI became 4+ and the MI was negative, so minocycline
was stopped and he continued on ofloxacin and clofazimine.
Pleasure noted that considerable research interest has arisen about the use of minocycline
for diseases of the central nervous system because of the increasing evidence about its neuroprotective effects.
As initial antibiotics during hospitalization, minocycline
was administered to 15 children, azithromycin to six children, tosufloxacin (quinolone) to four children, clarithromycin to two children, clindamycin to two children, and clarithromycin plus clindamycin to one child.
Medical record review later revealed that the decedent had a history of alcohol abuse, chronic obstructive pulmonary disease, congestive heart failure, and chronic osteomyelitis treated by minocycline
100 mg twice daily.
, but not ascorbic acid, increases motor activity and extends the life span of drosophila melanogaster.
Murray has ordered minocycline
, a related tetracycline-class antibiotic, to replace doxycycline for the tick-borne ehrlichiosis and anaplasmosis that he commonly sees in southern Arizona, as well as for treating kennel cough.