minimal erythema dose


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minimal erythema dose

, minimum erythema dose Abbreviation: MED
The shortest exposure to ultraviolet radiation that produces reddening of the skin within 1 to 6 hr and disappears in 24 hr. The minimal erythemal dose is used to calculate the duration of therapeutic exposure to ultraviolet light. For treatment using a “hot” ultraviolet lamp (UV-A or UV-B), the dose is calculated at a distance of 30 in. The minimal erythemal dose for “cold” ultraviolet (UV-C) is standardized at 30 to 38 sec at a distance of 1 in. Synonym: erythema dose; threshold dose See: table

CAUTION!

Burning, edema, and peeling occur at doses at or above the second degree erythemal dose.
DoseDescription
Suberythemal dose (SED)No erythema
Minimal erythemal dose (MED)Smallest dose that produces erythema within 1 to 6 hr and disappears within 24 hr
First degree erythemal dose (E1)Erythema lasts for 1 to 3 days. Some scaling of the skin is present. E1 is approximately 2.5 times the MED.
Second degree erythemal dose (E2)Erythema with associated edema, peeling, and pigmentation. E2 is approximately 5 times the MED.
Third degree erythemal dose (E3)Severe erythema and burning with associated blistering, peeling, and edema. E3 is approximately 10 times the MED.
See also: dose
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References in periodicals archive ?
Outcome measures consisted of skin blood flow, skin biopsy, and minimal erythema dose (MED).
Ultraviolet transmission measurements verified by determination of the minimal erythema dose with solar-simulated radiation.
Twenty-one healthy volunteers [either untreated or treated with oral psoralens (8-MOP or 5-MOP)] were enrolled in this study and exposed to solar radiation for evaluation of the following clinical parameters: immediate pigment darkening (IPD), minimal erythema dose (MED), minimal melanogenic dose (MMD), and minimal phototoxic dose (MPD) before and after topical or oral administration of PL.
Traditional phototherapy is limited by its ability to deliver only a minimal erythema dose (MED) to avoid burning healthy skin at the margins of psoriasis.

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