minimal detectable concentration

minimal detectable concentration

The lowest concentration of an analyte in a (fluid or tissue) specimen that can be reliably detected.

minimal detectable concentration

Lab medicine The lowest concentration at which an analyte can be reliably detected
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The minimal detectable concentration of colchicine is 1.0 ng on column in the current assay.
Sensitivity can be defined either as the minimal detectable concentration or the slope of the dose-response standard curve.
In these papers, no less than 5 different parameters have been discussed: the lower limit of detection (LLD), the biological detection limit (BDL), functional sensitivity (FS), the residual cancer detection limit (RCDL), and the minimal detectable concentration (MDC).
Given that a definition is a "statement of meaning" [2][3], and a term is "a spoken or written representation of a concept" [2][3], the title seems to put the cart before the definitive horse, in that the term being "defined" by the report is actually the "minimal detectable concentration (MDC)," by which the authors mean "the smallest analyte concentration an immunoassay can measure." The concept embodied in the author's definition is synonymous with "quantitation limit" or "limit of quantitation (LOQ)"-terms already defined by at least two authoritative bodies [3][4]:
The term "minimal detectable concentration," which we used to represent the concept of "the smallest analyte concentration an immunoassay can reliably measure," is synonymous with the concept of LOQ as defined by the NCCLS.
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