The outer surface of the minicell membrane is not only packed with gene silencing siRNA, but is also coated with antibodies, which lock onto (antigen) receptors on the tumour cells.
"The cancer cell then swallows the entire minicell," said Brahmbhatt.
Nguyen, "Study on Minicell Generation of Lactobacillus acidophilus VTCC-B-871 for Drug Delivery," J Appl Pharm Sci, vol.
Caption: FIGURE 4: The interaction between minicell membrane and molecule.
The first studies describing the antitumor immunotherapeutic properties of Salmonella enterica were conducted by Kurashige et al., using minicells (vesicles with no genomic DNA) obtained from Salmonella Typhimurium, and evaluated in two different murine models (sarcoma  and T-cell lymphoma ); they observed that the administration of these minicells restored macrophage activity in the tumor microenvironment, promoting tumor elimination.
Mitsuhashi, "Enhancing effects of minicells prepared from Salmonella typhimurium on anti-tumor immunity in sarcoma 180-bearing mice," Cancer Immunology Immunotherapy, vol.
The ability of miR-193a-3p to promote apoptosis was further demonstrated in MPM xenograft models when targeted by miR mimics delivered using EDV nanocells, bacterially-derived minicells
that can be packaged with a variety of cargoes and be delivered to tumors via bispecific antibodies attached on surface .
The platform is a first-in-class biodegradable delivery technology based on recombinant nanoparticles, called minicells
, derived from bacteria.
. Proc Natl Acad Sci USA 69:2927-2931 (1972).
According to the terms of the agreement, Lucent will provide Mobile Switching Centers based on the 5ESS(r) Switch platform, PCS Minicells
, and the GALAXY Power System 4848 and Unigy(r) II batteries.
* NovAtel Communications' Supplementary Cellular System (SCS) may cut subscriber bills through "minicells
" of five-mile radius.
He said that these "biobots" - or minicells
- could create the kind of microscopic features needed on microprocessors, or gene chips, used to test for millions of specific DNA sequences at once, reports New Scientist.