mini-chromosome

mini-chromosome

(1) An artificial chromosome created by linking restriction endonuclease digested fragments of DNA.
(2) An extremely small chromosome composed of centromeres and telomeres, in contrast to a conventional chromosome, which also has a large amount of introns (intervening DNA).

New genes can be stacked onto mini-chromosomes, making it much easier to move the genes to target sites, in contrast to traditional genetic modification in which genes are incorporated into a vector and difficult to manipulate.
References in periodicals archive ?
In old blood-forming stem cells, the researchers found a scarcity of specific protein components needed to form a molecular machine called the mini-chromosome maintenance helicase, which unwinds double-stranded DNA so that the cell s genetic material can be duplicated and allocated to daughter cells later in cell division.
Among the topics are dormant replication origins, break-induced DNA replication, the mini-chromosome maintenance replicative helicase, the spatial and temporal organization of DNA replication in bacteria and eukarya, DNA replication timing, replication-fork dynamics, sister chromatid cohesion, translesion DNA polymerases, rescuing stalled or damaged replication forks, genome instability in cancer, regulating DNA replication in plants, endoreplication, the archaeology of eukaryotic DNA replication, human mitochondrial DNA replication, whether human papillomavirus infections are warts or cancer, and adenovirus DNA replication.
European firm Bayer CropScience and Chromatin Inc (Chicago, Illinois) have announced that they have entered into a technological alliance and license agreement to use Chromatin's proprietary mini-chromosome technology for crop improvement.
This piece of DNA that has been used successfully to track maternal lineage is a unique mini-chromosome called mitochondrial DNA, or mtDNA.
Chromatin's proprietary mini-chromosome technology allows the simultaneous introduction of multiple genes into plants without disrupting the plant's own chromosomes.