mineralocorticoid


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mineralocorticoid

 [min″er-al-o-kor´tĭ-koid]
any of a group of hormones elaborated by the cortex of the adrenal gland, so called because of their effects on sodium, chloride, and potassium concentrations in the extracellular fluid. They are the adrenocortical hormones that are essential to the maintenance of adequate fluid volume in the extracellular and intravascular fluid compartments, normal cardiac output, and adequate levels of blood pressure. Without sufficient supply of the mineralocorticoids, fatal shock from diminished cardiac output can occur very quickly.

The principal mineralocorticoid is aldosterone, which accounts for most of the activities of this group of hormones. The primary effects of the mineralocorticoids are increasing the reabsorption of sodium and the secretion of potassium in the renal tubules. Secondary effects are related to the reabsorption of water, serum levels of sodium and potassium, anion reabsorption, and secretion of hydrogen ions. The net result of these activities is maintenance of fluid and electrolyte balance and, therefore, adequate cardiac output.

min·er·al·o·cor·ti·coid

(min'ĕr-al-ō-kōr'ti-koyd),
One of the steroids of the adrenal cortex that influences water and electrolyte (particularly sodium and potassium ions) metabolism and balance.
Synonym(s): mineralocoid

mineralocorticoid

(mĭn′ər-ə-lō-kôr′tĭ-koid′)
n.
Any of a group of steroid hormones, such as aldosterone, that are secreted by the adrenal cortex and regulate the balance of water and electrolytes in the body.

mineralocorticoid

Any of the steroid hormones that regulate water and electrolyte equilibrium, acting specifically on renal tubules.

mineralocorticoid

 Any of the steroid hormones–the most important is aldosterone–that regulate water and electrolyte equilibrium, acting specifically on renal tubule

min·er·al·o·cor·ti·coid

(min'ĕr-ăl-ō-kōr'ti-koyd)
One of the steroids of the cortex of the suprarenal gland that influence salt (sodium and potassium) metabolism.
Compare: bioregulator

min·er·al·o·cor·ti·coid

(min'ĕr-ăl-ō-kōr'ti-koyd)
One of the steroids of the cortex of the suprarenal gland that influences water and electrolyte metabolism and balance.
References in periodicals archive ?
It has both mineralocorticoid activity and some steroid activity, so certain patients can be maintained on fludro cortisone only.
Major studies on mineralocorticoid receptor antagonist therapy (eplerenone) in central serous chorioretinopathy Eplerenone Authors Study design dose 25 mg/g (1 week), Prospective, uncontrolled followed by 50 Bousquet et al.
Because high levels of circulating DOC saturate the mineralocorticoid receptor under most circumstances, the severity of clinical features and the age onset of hypertension and hypokalemia appear to vary, even among patients with the same mutation (5,8).
Inadequate mineralocorticoids may lead to vomiting due to salt-wasting leading to dehydration and death.5 In this report, we present a case of CAH presenting in skin OPD with diffuse hyperpigmentation.
Further studies on the mechanism of the mineralocorticoid action of licorice in humans.
It has been suggested that fludrocortisone has not only mineralocorticoid but also potent glucocorticoid activity [9].
These studies showed that the incidence of adverse events related to mineralocorticoid excess was higher in the abiraterone group than the placebo group.
Fludrocortisone acetate is a synthetic adrenocortical steroid with predominantly mineralocorticoid action.
As far as changes in medication during the observation period are concerned, the use of loop diuretics decreased by 11% in Group I and increased by 4.2% in Group II, beta-blocker use increased by 21.3% in Group I and by 0.9% in Group II, the use of ACE inhibitors or angiotensin receptor antagonists increased by 1.5% in Group I and decreased by 10.5% in Group II, and the use of mineralocorticoid receptor inhibitors decreased by 8.6% in Group I and increased by 1.8% in Group II.
Aldosterone is a steroid hormone and a mineralocorticoid with the most influence in mammals on the control of fluids and electrolytes [32, 33].
Elevated serum glucocorticoid hormone levels are caused by systemic or endogenous steroids that act by binding to the glucocorticoid receptor (GR) and to the mineralocorticoid receptor (MR).
The accumulation of mineralocorticoid precursors (mainly, deoxycorticosterone and corticosterone) causes hypokalemic alkalosis and hypertension.