mimotope


Also found in: Wikipedia.

mimotope

A novel peptide sequence which immunologically mimics an antigen’s epitope and has a 3-dimensional conformation, but not sequence homology, similar to the antigenic site. Mimotopes evoke an identical antibody response, and thus are potentially useful in developing vaccines.

mimotope

, mimetope (mĭm′ŏ-tōp″) [From mim(ic) + (epi)tope]
A small peptide that elicits a stronger antibody response than the polysaccharide or nucleic acid antigen that it is designed to mimic. Polysaccharide and nucleic acid antigens are often weakly immunogenic.
References in periodicals archive ?
However, The current analytical platforms have been unable to handle the huge amounts of data that need to be analysed for the discovery of new biomarkers, And as a result: (1) only a small number of new biomarkers have been discovered and (2) current routine diagnostic tests are able to provide only a very restricted overview of patients health status.protobios applies a ground-breaking high-throughput antibody repertoire characterization technology mimotope variation analysis (mva) to discover new biomarkers, Develop novel multiplexed diagnostics, And empower the discovery and development of therapeutics and vaccines.
In addition to native PGL-I, IgM levels can be measured by means of a synthetic mimotope: a natural disaccharide linked to bovine serum albumin (ND-OBSA) [15-17].
analyzed the therapeutic effect of DCs expressing a CD166 cross-reactive mimotope of the GD2 ganglioside 47-LDA in lymphodepleted NXS2 NB tumor-bearing syngeneic mice.
• Antibody Epitope Mapping Service - Mimotope Variation Analysis (MVA) based Epitope Mapping
The results of this study advance the generation of reliable and high-yield mimotope collections of HIV epitopes.
Project coordinator from Austrian company Affiris Dr Frank Mattner, said this was the result of previous human-trialled vaccines: "Some of the patients developed an auto-immune disease." He said Mimovax would use a "mimotope ...
americana component previously shown to be an allergenic molecule were used to identify the MAb-bound mimotope and its phylogenic distribution.
Identification of mimotope peptides which bind to the mycotoxin deoxynivalenol-specific monoclonal antibody.
All sixty peptide sequences were analysed in mimotope database (MimoDB 2.0) to check if the peptide sequences identified in this study have any other targets (32) and SAROTUP software (target unrelated peptide scanner) to check presence of any target unrelated peptides (33).
Protobios's Mimotope Variation Analysis (MVA) technology gives a detailed description of epitopes and mimotopes and has several advantages over other technologies.
Chaves-Moreira et al., "Evaluation of the protective potential of a Taenia solium cysticercus mimotope on murine cysticercosis," Vaccine, vol.