While at micromolar concentrations, biguanides confer antineoplastic action; at millimolar
ones, they inhibit mitochondrial respiratory chain complexes and are toxic for all the cells.
The concentration of cellular polyamines is typically low and is precisely controlled by metabolic modulation including polyamine uptake, transport, and interchange ; thus the intracellular concentration of polyamines is generally in the millimolar
Calpain 2, however, belongs to the m-calpain group and requires millimolar
changes in [Ca.sup.2+] levels to induce its activity.
fermentans numerically increased in colony numbers from November to February and produces mainly yeast-like cells on media containing millimolar
concentrations of urea and diammonium phosphate (O'Brien et al., 2007; Sanna et al., 2012).
Glutathione (GSH), a cysteine- containing tripeptide, is a key antioxidant present in millimolar
concentrations in cells.
This method is a "gold standard" method for the determination of MG concentration in the millimolar
Alpha-7 nicotinic receptors can also be activated by choline itself, at millimolar
concentrations, many orders of magnitude higher than the concentrations required for activation by acetylcholine.
Glutathione is the major antioxidant of low molecular weight containing SH group present in mammalian cells, in millimolar
amounts in most cells.1 All forms of mercury regardless physical or chemical form are one of the most dangerous pollutants in environment.2-4 There are evidences that mercury reacts with reduced form of glutathione due to which in many specific types of cells glutathione contents are decreased as in human erythrocytes5,6 indicating that GSH is the big oxidant protectant.
(1995) Axotomy induces a transient and localized elevation of the free intracellular calcium concentration to the millimolar
Physiological plasma concentrations of C4 are in the micromolar range , whilst in previous studies C4 has been used in the millimolar
Glutathione (GSH) is present in eukaryotic cells at millimolar
concentrations and plays direct or indirect roles in many important biological phenomena, including metabolic activity and cell defence against several pathogens, like viruses (Nencioni et al., 2011).
Strong acids produced by metabolism of ethylene glycol and methanol are present in appreciable millimolar
concentrations and are detectable as an increased anion gap.