milbemycin

milbemycin

(mil-be-mī'sin),
A macrocyclic lactone (macrolide) antiparasiticide used for prevention of heartworm caused by Dirofilaria immitis, treatment of Toxacara canis, Toxascaris leonina, Trichuris vulpis, and Ancylostoma caninum gastrointestinal (GI) parasites in heartworm-negative dogs; also has activity against ectoparasites such as Demodex sp.; in the avermectin family; derived from 5-didehydromilbemycin moiety from Streptomyces hygroscopicus subsp. aureolacrimosis; less toxic in Collies than ivermectin; given monthly orally. In cats, labeled for Dirofilaria immitis prevention, and treatment of GI parasites TOXACARA CATI and Ancylostoma tubaformae. Enhances gamma amino butyric acid release at the presynaptic membrane resulting in parasite paralysis and death. Not effective against flukes and tapeworms.
References in periodicals archive ?
Sentinel contains lufenuron plus milbemycin oxime, which is used for heartworm prevention and for the treatment of hookworms, roundworms, and whipworms.
Compounds without defined structures, for example, oils or mixtures such as milbemectin(containing milbemycin A4 and milbemycin A3), were excluded from the evaluation.
Reversal of P-glycoprotein-mediated multidrug resistance in vitro by milbemycin compounds in adriamycin-resistant human breast carcinoma (MCF-7/adr) cells.
Huanget al., "Simultaneous determination of avermectin and milbemycin residues in bovine tissue by pressurized solvent extraction and LC with fluorescence detection," Chromatographia, vol.
This agreeable behavior change stopped when he was given the heartworm medication Interceptor (milbemycin oxime).
The role of ivermectin, milbemycin, and other heartworm preventive medications commonly used in dogs and cats is unknown.
Improved canine chemoprophylaxis may require combinations or sequential dosages of the macrocyclic lactones including ivermectin, moxidectin, selamectin, and milbemycin oxime; or by adding another effective antifilarial medication, such as melarsomine dihydrochloride to the prophylactic regimen.
ABCB1-1[DELTA] (MDR1-1[DELTA]) genotype is associated with adverse reaction in dogs treated with milbemycin oxime for generalized demodicosis.
A combination with milbemycin oxime extends the spectrum of activity to include nematodes.
(8.) White SD, Rosychuk RA, Fieseler KV: Clinicopathologic findings, sensitivity to house dust mites and efficacy of milbemycin oxime treatment of dogs with Cheyletiella sp.