ATP1A2(redirected from migraine, hemiplegic 2)
ATP1A2A gene on chromosome 1q21-q23 that encodes an alpha 2 (catalytic) subunit of the family of P-type cation transport ATPases and subfamily of Na+/K+ -ATPases. These Na+/K+ -ATPases are heterodimers composed of a large alpha subunit and a smaller beta subunit, and are responsible for establishing and maintaining the electrochemical gradients of Na and K ions across plasma membranes. These electrochemical gradients are required for osmoregulation, sodium-coupled transport of various organic and inorganic molecules and electrical excitability of nerve and muscle.
ATP1A2 mutations are linked to familial basilar or hemiplegic migraines, and alternating hemiplegia of childhood.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.