midkine


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midkine

A retinoic acid-responsive, heparin-binding growth factor encoded by MDK on chromosome 11p11.2, which is expressed by various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration.

Molecular pathology
Midkine is expressed in various malignances (e.g., Wilm’s tumour and neuroblastomas), suggesting a role tumour development, perhaps through angiogenesis.
References in periodicals archive ?
The authors showed that midkine was able to mediate the formation of NETs as well as the accumulation of neutrophils in inflamed heart tissue.
Zhang et al., "Midkine positively regulates the proliferation of human gastric cancer cells," Cancer Letters, vol.
Herradon, "Regulation of extinction of cocaine-induced place preference by midkine is related to a differential phosphorylation of peroxiredoxin 6 in dorsal striatum," Behavioural Brain Research, vol.
Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine. Nature.
Taking all these data into consideration, we designed a prospective trial to test the hypothesis whether midkine could represent an early biomarker of contrast nephropathy in patients with normal serum creatinine.
FGF-5 inhibitor hair growth products In 2010 Cellmid set up a dedicated subsidiary, Advangen International Pty Ltd, for the development of midkine for hair growth.
In the case of CD, MMP-9 positively correlated with CDAI, CRP, IL-1, IL-6, PLT, WBC, midkine, VEGF A, and PDGF-BB.
van Huyen et al., "Midkine is involved in kidney development and in its regulation by retinoids," Journal of the American Society of Nephrology, vol.
(172-174) The distribution overlap of ALK with members of the TRK neurotrophin RTKs suggests that ALK may be a receptor for neurotrophic factors such as the related proteins midkine and pleiotrophin.
Several proteins (midkine, interleukin 4, p18, 18 kDa phosphoprotein, SUMO-protein ligase PIAS2, abhydrolase bundle transporter protein, the precursor of usher, tet oncogene family member 2 isoform b, twinfilin-1, SUMO-protein ligase PIAS2, prolactin secretor hormone receptor, protein phosphatase 1 regulatory subunit 12A, never in mitosis gene a (NIMA)-related kinase, mitochondrial protein, mitochondria) actin binding protein 1) in our proteomic analyses represent an important step to elucidate how Ankaferd regulates cell cycle and other biological actions of the tumor tissue.
Rohrer, "Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition," Development, vol.