midkine


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midkine

A retinoic acid-responsive, heparin-binding growth factor encoded by MDK on chromosome 11p11.2, which is expressed by various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration.

Molecular pathology
Midkine is expressed in various malignances (e.g., Wilm’s tumour and neuroblastomas), suggesting a role tumour development, perhaps through angiogenesis.
References in periodicals archive ?
In the whole group studied we found a significant rise in serum midkine as early as after 2 hours (P < 0.
Midkine was significantly higher 2, 4, and 8 hours after PCI in patients with CIN (Figure 1), while NGAL levels were significantly higher in patients with CIN starting 2 hours after PCI (serum NGAL) or 4 hours (urinary NGAL).
Midkine correlated in univariate correlation with time of PCI (r = 0.
We have found that midkine is a sensitive marker of renal injury after contrast administration in low-risk patients undergoing percutaneous coronary interventions.
Cellmid holds the largest and most comprehensive portfolio of intellectual property related to the novel oncology target midkine and midkine antagonists globally.
The licence deal was contingent on whether the Japanese company would reach accuracy of 500 picogram/ml midkine on its latex platform using Cellmid's antibodies.
Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis.