middle molecule


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molecule

 [mol´ĕ-kūl]
a group of atoms joined by chemical bonds; the smallest amount of a substance that possesses its characteristic properties.
adhesion m's (cell adhesion m's (CAM)) cell surface glycoproteins that mediate intercell adhesion in vertebrates.
middle molecule any molecule that has an atomic mass between 350 and 2000 daltons; these accumulate in the body fluids of patients with uremia.

middle molecule

A molecule having a size of at least 500 daltons (Da) and no more than 30,000 Da, presumed to be an endogenous poison that accumulates in the body of patients with chronic kidney disease or uremia. Clearance of these molecules is a goal of hemodialysis. Synonym: middle-molecular-weight solute
References in periodicals archive ?
* Improved dialysis efficiency for both small and middle molecules
Despite considerable effort, the elusive middle molecule was never identified and is more concept than reality.
Large middle molecules may affect a range of biological functions, including inflammation and cardiovascular risk.
Analysis of the contents of middle molecules in the sperm of men of all age groups living in village Shalkar showed a significant change in the content of middle-mass molecules, which indicates a high level of endogenous intoxication in the cells and is associated with changes in ecological trouble of the region.