This benign middle ear adenoma (a neuroendocrine tumor) shows bone invasion of the ossicles, but it is still a benign neoplasm (hematoxylin-eosin, original magnification X400).
There is a cholesteatoma intimately associated with a middle ear adenoma (hematoxylin-eosin, original magnification X200).
World Health Organization Classification of the Histologic Types of the Tumors of the Ear and the Temporal Bonea Descriptor ICD-O Codes (b) Squamous cell carcinoma 8070/3 Ceruminous adenocarcinoma 8420/3 Ceruminous adenoid cystic carcinoma 8200/3 Ceruminous mucoepidermoid carcinoma 8430/3 Ceruminous adenoma 8420/0 Ceruminous pleomorphic adenoma Ceruminous syringocystadenoma papilliferum Middle ear adenoma (carcinoid) Middle ear adenocarcinoma Aggressive papillary tumor 8260/1 Endolymphatic sac tumor 8140/3 Vestibular schwannoma 9560/0 Meningioma 9530/0 (a) Reproduced with permission from the World Health Organization (WHO)/International Agency for Research on Cancer.
Diversity of expression and clinical behavior of these tumors explain the variant terminology used to describe them, including middle ear adenoma, adenomatous tumor, neuroendocrine adenoma, carcinoid tumor, and mixed epithelial and neuroendocrine tumor [13, 14].
Pearl, "Middle ear adenoma," Archives of Pathology and Laboratory Medicine, vol.
Middle ear adenoma. A tumor displaying mucinous and neuroendocrine differentiation.
Middle ear adenoma with neuroendocrine differentiation.
Middle ear adenoma
. A cytologically uniform neoplasm displaying a variety of architectural patterns.
The most common primary tumors are paragangliomas (glomus tumors), followed by middle ear adenomas
in adults and by hemangiomas in children.
Uncommon benign tumors include hemangiomas and middle ear adenomas
. These will generally demonstrate well-circumscribed margins and may be difficult to differentiate from congenital cholesteatomas.