microvessel density


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microvessel density

The concentration of small blood vessels in a malignant tumor. It reflects the amount of angiogenesis within the tumor and has been correlated with the ability of tumors to grow and metastasize.
See also: density
References in periodicals archive ?
40% of fibrocystic breast disease cases without hyperplasia showed mild grade microvessel density score (MVD Score), while 20% showed severe grade MVD score.
Tumour angiogenesis, as assessed by microvessel density (MVD), shows significant correlation with poor prognosis in several human cancers, including urological cancers.
Table 1: Correlation of Ki-67 labeling index (Ki-67 LI), PCNA labeling index (PCNA LI) and microvessel density (MVD) with the gender of the cases.
2004) reported that tamoxifen and quercetin acted synergistically to reduce tumor volume, VEGF expression, and microvessel density in prostate tumor xenograft mice.
Increased expression of CD146 and microvessel density (MVD) in invasive micropapillary carcinoma of the breast: comparative study with invasive ductal carcinoma-not otherwise specified.
No significant relationship was found between microvessel density, age, stage, diameter, or grade of the tumour and tumoral mast cell count (p Greater than 0.
Additionally, curcumin-treated mice experienced a reduction in vascular endothelial growth factor (VEGF), indicating reduced angiogenesis, as well as significantly lower microvessel density in adipose tissue.
The intratumoral microvessel density (MVD) was significantly higher in the HBO group (15.
The wide array of molecular-based PCa markers includes proliferation index (Ki-67), microvessel density, nuclear morphometry, tumor suppressor genes (eg, TP53, CDKN1A, CDKN1B, NKX3-1, PTEN, and the retinoblastoma gene Rb), oncogenes (eg, BCL2, MYC, EZH2, and ERBB2 [formerly HER2/neu]), adhesion molecules (eg, CD44 and E-cadherin), the PI3K/Akt/mTOR (mammalian target of rapamycin) pathway, (30,31) apoptosis regulators (eg, survivin and transforming growth factor p1), androgen receptor status, neuroendocrine differentiation markers, and prostate tissue lineage-specific markers (PSA, prostate-specific acid phosphatase, and prostate-specific membrane antigen).
This could be explained by the higher microvessel density of RCCs vs RO.