microvessel density


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microvessel density

The concentration of small blood vessels in a malignant tumor. It reflects the amount of angiogenesis within the tumor and has been correlated with the ability of tumors to grow and metastasize.
See also: density
References in periodicals archive ?
Interestingly, the rim of the metastatic tumour area also showed an increase in microvessel density histologically, but in this region, CBF measured by MP pCASL MRI was normal.
Between D3 and D14, microvessel density increased significantly in the PB-MNC+ group (P = 0.032) but was not significantly modified in the PB-MNC or PBS groups.
Severe grade microvessel density was seen in 33% of grade I cases 50% of grade II cases and 70% of grade III cases.
de Torres, "Study of microvessel density and the expression of the angiogenic factors VEGF, bFGF and the receptors Flt-1 and FLK-1 in benign, premalignant and malignant prostate tissues," Histology and Histopathology, vol.
In conclusion, our meta-analysis showed that [SUV.sub.max] may predict microvessel density and expression of VEGF, KI 67, and HIF-1[alpha] in lung cancer.
Lian et al., "Endocan-expressing microvessel density as a prognostic factor for survival in human gastric cancer," World Journal of Gastroenterology, vol.
Keywords: Mast cells, Renal cell carcinoma, Microvessel density, Angiogenesis.
Folkman, "Clinical application of antiangiogenic therapy: microvessel density, what it does and doen't tell us," Journal of the National Cancer Institute, vol.
Suh, "Correlations of 3T DCE-MRI quantitative parameters with microvessel density in a human-colorectal-cancer xenograft mouse model," Korean Journal of Radiology, vol.
Pathological significance and prognostic role of microvessel density, evaluated using CD31, CD34, and CD105 in prostate cancer patients after radical prostatectomy with neoadjuvant therapy.
Patients who responded well were most likely to have a significant decrease in microvessel density, whereas patients with stable or increased microvessel density experienced a relapse (15).
The wide array of molecular-based PCa markers includes proliferation index (Ki-67), microvessel density, nuclear morphometry, tumor suppressor genes (eg, TP53, CDKN1A, CDKN1B, NKX3-1, PTEN, and the retinoblastoma gene Rb), oncogenes (eg, BCL2, MYC, EZH2, and ERBB2 [formerly HER2/neu]), adhesion molecules (eg, CD44 and E-cadherin), the PI3K/Akt/mTOR (mammalian target of rapamycin) pathway, (30,31) apoptosis regulators (eg, survivin and transforming growth factor p1), androgen receptor status, neuroendocrine differentiation markers, and prostate tissue lineage-specific markers (PSA, prostate-specific acid phosphatase, and prostate-specific membrane antigen).