These data included donor age, gender, body mass index (BMI), biopsy findings (hydrops, sinusoidal dilatation, pigment accumulation, inflammatory infiltration, parenchymal focal necrosis, microvesicular steatosis
, and macrovesicular steatosis), graft type, volumetric analysis of the liver calculated by multi-slice computerized tomography (CT) [total liver volume (TLV), functional liver volume (FLV), graft volume (GV), remnant liver volume (RLV), percentage of remnant liver volume to total liver (RLV%), remnant liver to donor body weight ratio (RLBWR)], graft weight after hepatectomy (GW), peri-operative use of blood transfusion, fresh frozen plasma (FFP), amounts of crystalloid and colloid solutions, operation time, as well as intraoperative and postoperative complications.
Cases in which histopathology sections were showing mainly microvesicular steatosis
and those cases where aetiology of steatosis could not be confirmed were excluded from the study.
Severe hepatic steatosis was observed in the HF group (c) with the presence of macro- and microvesicular steatosis
and inflammatory infiltrate.
, as seen with tetracycline and valproate, results from acute impairment of [beta] oxidation of fatty acids in mitochondria.
Table 1 Classification of drug-induced liver injury and associated psychotropics Pattern of liver injury Psychotropic agent Acute Bupropion Hepatocellular (ALT >3 x upper limit of Fluoxetine normal) Nefazodone (a) Paroxetine Risperidone Sertraline Trazodone Valproic acid Cholestatic (AP >2 x upper limit of normal, Chlorpromazine ALT/AP <2) Phenothiazines Tricyclics Mixed ([up arrow]AP and ALT) Amitriptyline Carbamazepine Phenobarbital Phenytoin Chronic Microvesicular steatosis
Valproic acid (a.
Histological changes are similar to those observed in the Reye's syndrome, with early production of microvesicular steatosis
followed by the development of centrilobular necrosis.
In the histological analysis of the liver, we detected microvesicular steatosis
in HFD-fed mice (Figure 1).
can occur with valproate, antiretrovirals, pregnancy-related hepatic conditions, and inborn errors of metabolism.
SAN DIEGO -- Microvesicular steatosis
may be more common in patients with nonalcoholic fatty liver disease than previously thought and is associated with markers of severe disease, a study of 1,022 biopsies suggests.
Impaired mitochondrial function in microvesicular steatosis
is a less common but more severe variant, resulting primarily from deficient mitochondrial [beta]-oxidation of fatty acids and characterized by the presence of multiple small droplets of triglyceride within the hepatocyte, which do not displace the nucleus [89, 90].
is defined by multiple small lipid droplets in the hepatocyte without nuclear dislocation, as compared with macrovesicular steatosis, which is usually composed of a large cytoplasmic lipid vacuole that displaces the nucleus peripherally.