microvesicular steatosis

microvesicular steatosis

The presence of multiple 1-µ droplets of fat in liver cells, damage/necrosis and giant mitochondria, which is not always identifiable on H&E staining.
 
Aetiology
Reye syndrome (panacinar) due to aspirin; alcohol (perivenular); drugs; infectious (e.g., HAV, HDV, Salmonella); HELLP; acute fatty liver of pregnancy.
References in periodicals archive ?
In the histological analysis of the liver, we detected microvesicular steatosis in HFD-fed mice (Figure 1).
Microvesicular steatosis is defined by multiple small lipid droplets in the hepatocyte without nuclear dislocation, as compared with macrovesicular steatosis, which is usually composed of a large cytoplasmic lipid vacuole that displaces the nucleus peripherally.
Microvesicular steatosis is a common finding and can occur following warm ischemia.
Microvesicular steatosis can occur with valproate, antiretrovirals, pregnancy-related hepatic conditions, and inborn errors of metabolism.
The picture was quite different from the panlobular microvesicular steatosis of Reye's syndrome (22) or that of viral hepatitis or infectious diseases involving the liver, such as melioidosis, typhoid fever or malaria.
Impaired mitochondrial function in microvesicular steatosis.
Microvesicular steatosis is a less common but more severe variant, resulting primarily from deficient mitochondrial [beta]-oxidation of fatty acids and characterized by the presence of multiple small droplets of triglyceride within the hepatocyte, which do not displace the nucleus [89, 90].
SAN DIEGO -- Microvesicular steatosis may be more common in patients with nonalcoholic fatty liver disease than previously thought and is associated with markers of severe disease, a study of 1.
The presence of striking microvesicular steatosis suggested amiodarone toxicity.
4]) cell necrosis, inflammation, 2 mg/kg, 24 hr microvesicular steatosis 56-23-5 Fluka Hydrazine Hepatocellular necrosis with 60 mg/kg, 24 hr inflammation, mild microvesicular 302-01-2 steatosis Sigma Thioacetamide Hepatocellular vacuolation and 50 mg/kg, 24 hr necrosis 62-55-5 Sigma-Aldrich 1,2-Dichlorobenzene Centrilobular to midzonal hepato- 4,500 mmol/kg, 24 hr cellular hydropic swelling, necrosis 95-50-1 with mixed inflammation Fluka Coumarin Hepatocellular hypertrophy, single- 200 mg/kg, 24 hr cell necrosis, lymphocytic 91-64-5, infiltration Sigma Acetaminophen Centrilobular hepatocellular 2 g/kg, 24 hr vacuolation, single-cell necrosis, 103-90-2 inflammation Fluka Amineptine Hepatocellular microvesicular 0.
Upon hematoxylin and eosin tissue staining, rats fed the chow diet and given repeated alcohol binges showed minimal steatosis, while rats fed the [choline-deprived] diet and given repeated whisky binges showed periportal and pericentral microvesicular steatosis.
A percutaneous liver biopsy, performed at the bedside under ultrasonographic guidance, showed macrovesicular and microvesicular steatosis, with central hepatocellular nuclei and essentially no intralobular inflammation (Figs.