microvesicular steatosis

microvesicular steatosis

The presence of multiple 1-µ droplets of fat in liver cells, damage/necrosis and giant mitochondria, which is not always identifiable on H&E staining.
 
Aetiology
Reye syndrome (panacinar) due to aspirin; alcohol (perivenular); drugs; infectious (e.g., HAV, HDV, Salmonella); HELLP; acute fatty liver of pregnancy.
References in periodicals archive ?
However, the presence of microvesicular steatosis on core liver biopsy eventually confirmed the diagnosis of AFLP.
Brunt et al., "Presence and significance of microvesicular steatosis in nonalcoholic fatty liver disease," Journal of Hepatology, vol.
The liver biopsy results showed mild macrovesicular and microvesicular steatosis with mild portal and lobular inflammation.
Liver biopsy showed severe macro- and microvesicular steatosis with associated severe fibrosis and portal ductular reaction (Figure 1).
These data included donor age, gender, body mass index (BMI), biopsy findings (hydrops, sinusoidal dilatation, pigment accumulation, inflammatory infiltration, parenchymal focal necrosis, microvesicular steatosis, and macrovesicular steatosis), graft type, volumetric analysis of the liver calculated by multi-slice computerized tomography (CT) [total liver volume (TLV), functional liver volume (FLV), graft volume (GV), remnant liver volume (RLV), percentage of remnant liver volume to total liver (RLV%), remnant liver to donor body weight ratio (RLBWR)], graft weight after hepatectomy (GW), peri-operative use of blood transfusion, fresh frozen plasma (FFP), amounts of crystalloid and colloid solutions, operation time, as well as intraoperative and postoperative complications.
Likewise, NAFLD grading showed that, of the WT-HFD mice, three had stage 2 (predominantly microvesicular steatosis with mild lobular inflammation), three had stage 3 (mixed steatosis with lobular inflammation and ballooning degeneration), and one had stage 4 (mixed steatosis with lobular inflammation and ballooning degeneration and macrovesicular steatosis, associated with portal and lobular inflammation, Councilman's bodies, ballooning degeneration, Mallory's hyaline, and fibrosis) NAFLD.
Arrows indicated appearance of prominent microvesicular steatosis. Values were presented as the mean [+ or -] SD.
As shown in Figures 2(a) and 2(b), mice fed the HFD developed severe macrovesicular and microvesicular steatosis without apparent inflammatory cell infiltration and fibrosis, while there appeared to be an attenuated state of steatosis with notable reduction in the number of vacuolar areas in both Curc-mPEG454 treatment groups.
Cases in which histopathology sections were showing mainly microvesicular steatosis and those cases where aetiology of steatosis could not be confirmed were excluded from the study.
Microvesicular steatosis, as seen with tetracycline and valproate, results from acute impairment of [beta] oxidation of fatty acids in mitochondria.
According to these criteria, macrovesicular steatosis is quantified based on the percentage of involved hepatocytes (0 = absent; 1 < 33%; 2 = 33-66%; 3 > 66%), and its zonal distribution and the presence of microvesicular steatosis are noted; hepatocellular ballooning is evaluated for zonal location, and the estimate of its severity (mild, marked) is based on the numbers of hepatocytes showing this abnormality [20].