gastric perfusion), which is important in view of the known heterogeneity in microvascular perfusion
within the gastrointestinal tract.
A, Photograph of the experimental set up used in the assessment of skin microvascular perfusion
using laser speckle contrast imaging coupled with iontophoresis of vasodilator drugs.
They found that absent microvascular perfusion
after PCI was significantly more common in patients with longer DBT and MBG 0/1 and STR <30% identified patients with increased 3-year mortality.[sup] Our results were consistent with findings that IABP therapy was associated with improved myocardial perfusion.
The authors showed that an improvement of the sublingual microvascular perfusion
was evident four hours after the initiation of the activated drotrecogin-[alpha] but decreased when the infusion ended.
The peripheral perfusion index (PPI), an indicator reflecting peripheral perfusion changes, is derived from the photoelectric plethysmographic signal of the pulse oximeter. This is a noninvasive technique that can use two different wavelengths of light (red and infrared) that are transmitted through the distal phalanx of the finger, resulting in the exhibition of a pulsatile photoplethysmographic waveform. In addition, the ratio of pulsatile and nonpulsatile components shown on the pulse oximetry signal has been related to peripheral perfusion. Another technique suggested to be an evaluation of microvascular perfusion
is sidestream dark field (SDF).
Microvascular reactivity was evaluated using an LSCI system with a laser wavelength of 785 nm (PeriCam PSI system, Perimed, Sweden), which enabled us to perform noninvasive and continuous measurements of cutaneous microvascular perfusion
changes, measured in arbitrary perfusion units (APU).
Clinical studies have shown that alterations in sublingual microvascular perfusion
are one of the strongest predictors of outcome and remain independently associated with outcome [12, 24].
The fundamental role played by the microcirculation in regulating oxygen delivery supports the belief that alterations in microvascular perfusion
are implicated in both organ dysfunction and multiple organ failure due to shock from a variety of aetiologies (3).
Tai et al., "Obstructive sleep apnea in patients admitted for acute myocardial infarction: prevalence, predictors, and effect on microvascular perfusion
," Chest, vol.
Intracoronary eptifibatide is associated with improved microvascular perfusion
demonstrated by an improved cTFC in the ICE trial .
Effects of fluids on microvascular perfusion
in patients with severe sepsis.
This can cause altered balances between endothelial vasoactive compounds (nitric oxide, prostacyclin), which then results in loss of vascular tone and microvascular perfusion