microtubule-associated proteins


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mi·cro·tu·bu·le-·as·so·ci·at·ed pro·teins (MAPs),

proteins that have a specific association with α- and/or β-tubulin; for example, tau, MAP1, MAP2; several have been found in the plaques observed in Alzheimer disease.
References in periodicals archive ?
LC3B (microtubule-associated proteins 1A/1B light chain 3B), another human LC3 gene family member, was stained positive in 63 out of 117 (53.8%) samples.
Tau protein plays an important role as a microtubule-associated protein in neuronal axons, stabilizing microtubules and inducing their assembly [48].
In the present study, we focus on the microtubule-associated protein tau (MAPT).
Microtubule-associated protein tau in development, degeneration and protection of neurons.
These seeding microtubule fragments should have retained a high level of microtubule-associated proteins. It is thus assumed that [C.sub.c] [approximately equal to] 2 [micro]M in [11].
Other neuronal marker proteins that have been identified in central neurocytoma include neurofilament protein, neuron-associated class III [beta]-tubulin, and microtubule-associated proteins MAP2 and tau.
In addition, phosphorylation of microtubule-associated proteins (MAPS) and actin-associated proteins may induce alterations of polymerization of MTs and distribution of MFs (30,31).
Microtubule-associated proteins (MAPs) have many subtypes, including MAP1A, MAP1B, MAP2, MAP4, and tau proteins.
JNK exerts its effects on the cytoskeleton by phosphorylating numerous microtubule-associated proteins (MAPs) such as MAP2, MAP1B, tau and the stathmin family microtubule-destabilizing protein SCG10.
On the molecular level, plectin binds to a variety of cytoskeletal proteins, including cytoplasmic and nuclear IF subunit proteins (vimentin, GFAP, cytokeratins, neuro-filament proteins, lamin B), subplasma membrane proteins (fodrin and [Alpha]-spectrin), and high molecular weight microtubule-associated proteins MAP1 and MAP2 (Herrmann and Wiche, 1987; Foisner et al., 1988; Wiche et al., 1993).
Such a bundling mechanism can be applied to a class of cationic actin-bundling proteins, including smooth muscle calponin and the microtubule-associated proteins tau and Map2c.

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