"The results therefore validate the unexplored extracellular technological potential to treat and heal diseases through precise regulation of
microtubule associated proteins."
The assembly and stability of microtubules are promoted by
microtubule associated proteins [25].
Upregulation of the
microtubule associated protein BIII-tubulin is associated with clinical resistance to these drugs, which is what makes the Benitec- CCIA approach so promising.
This region is important for anchoring
Microtubule Associated Protein (MAP) in place (27).
Upregulation of the
microtubule associated protein beta III-tubulin is associated with clinical resistance to these drugs, which is what makes the Benitec- CCIA approach so promising."This is a very exciting development and demonstrates how research conducted at the laboratory bench can be translated into better outcomes for patients," said A/Professor Kavallaris.ABOUT CCIAChildren's Cancer Institute Australia for Medical Research (CCIA) is the only independent medical research institute in Australia devoted to research into the causes, better treatments, prevention and cure of childhood cancer.
JNKs also have extranuclear targets such as Bcl family members [49] and
microtubule associated proteins such as tau [26, 27, 50].