microtubule


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Related to microtubule: Intermediate filaments

microtubule

 [mi″kro-tu´būl]
any of the slender, tubular structures, composed chiefly of tubulin, found in the cytoplasmic ground substance of nearly all cells; they are involved in maintenance of cell shape and in the movements of organelles and inclusions, and form the spindle fibers of mitosis.

mi·cro·tu·bule

(mī'krō-tū'byūl),
A hollow, cylindric cytoplasmic element, 25 nm in diameter and of variable length, that occurs widely in the cytoskeleton, cilia, and flagella of cells; microtubules play a role in the maintenance of cell shape and increase in number during mitosis and meiosis, in which they are related to movement of the chromosomes by the nuclear spindle.

microtubule

(mī′krō-to͞o′byo͞ol, -tyo͞o-)
n.
Any of the cylindrical hollow tubulin-containing structures that are found in the cytoplasm, cilia, and flagella of eukaryotic cells and are involved in determining cell shape and structure and directing the movement of organelles and chromosomes. Microtubules, along with microfilaments and intermediate filaments, make up a cell's cytoskeleton.

mi′cro·tu′bu·lar adj.

microtubule

A cylindrical tube measuring 20–25 nm in diameter, composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarised: at one end (the negative (-) end), alpha-subunits are exposed; at the other end (the positive (+) end), beta-subunits are exposed. Microtubules act as a scaffolding to determine cell shape, and provide a matrix on which cell organelles and vesicles move, a process requiring motor proteins, including kinesin (which moves towards the (+) end of the microtubule) and dynein (which generally moves towards the (-) end). Microtubules also form the spindle fibres for separating chromosomes during mitosis.

mi·cro·tu·bule

(mī'krō-tū'byūl)
A cylindric cytoplasmic element that occurs widely in the cytoskeleton of plant and animal cells; microtubules increase in number during mitosis and meiosis, where they may be related to movement of the chromosomes or chromatids on the nuclear spindle during nuclear division.

microtubule

or

neurotubule

a hollow filament about 20–25 nm in diameter found in EUKARYOTE cells, composed of ACTIN-like protein called tubulin. Microtubules are thought to make up the CYTOSKELETON of the cell, the spindle fibres of MEIOSIS and MITOSIS, (See also COLCHICINE and, in some cells of plants and animals, form the 9 + 2 structure of the CILIUM and FLAGELLUM.

mi·cro·tu·bule

(mī'krō-tū'byūl)
A cylindric cytoplasmic element that occurs widely in the cytoskeleton of plant and animal cells; microtubules increase in number during mitosis and meiosis.
References in periodicals archive ?
In contrast, in invertebrates, such as bivalves, oligochaetes, and starfish, the migration of the meiotic spindle depends on microtubules (Shimizu 1997, Pielak et al.
Several reports suggest the occurrence of an electrical storm among 10% to 20% of implantable cardioverter-defibrillator (ICD ) recipients.1-4 Microtubules are the key components of the cytoskeleton of eukaryotic cells and have an important role as railways in various cellular functions such as intracellular migration and vesicle transport, cell shape maintenance, polarity, cell signaling, and mitosis.5 In addition, colchicine binding to beta-tubulin results in curved tubulin dimer and prevents it from adopting a straight structure.
Bulinski et al., "Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics," Journal of Cell Biology, vol.
Through phosphorylation, tau protein may bind to the microtubules, thus supporting their proper functioning, yet hyperphosphorylation results in the loss of this feature.
McClellan et al., "Mechanism of microtubule lumen entry for the [alpha]-tubulin acetyltransferase enzyme aTAT1," Proceedings of the National Academy of Sciences of the United States of America, vol.
Some evidences showed that Cx transport was mediated partially by microtubules that are intrinsically polar: the plus-end is the fast-growing end and the minus-end is stable or serves as the site of disassembly [17].
Further examination of the microtubule arrays at telophase showed that the microtubules were arranged at the equatorial plate in the CK and B treatments (Fig.
Given that curcumin interacts with microtubules to suppress their dynamic instability (Banerjee et al., 2010; Chakraborti et al., 2011; Gupta et al., 2006), we observed the changes in microtubule filaments associated with its administration.
The pattern of microtubule bundle distribution was particularly striking in maximum-intensity, through-focus projections of confocal Z stacks (stacks of images collected via optical sectioning of the specimen in the z-axis) (Fig.
Stabilizing microtubules with Taxol causes the formation of elongated, oblique secondary cell wall pits in xylem vessels.

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