microspherocyte

microspherocyte

 [mi″kro-sfēr´o-sīt]
an erythrocyte whose diameter is less than normal, but whose thickness is increased.

microspherocyte

A small (< 4 µm), round red cell seen in a background of excess blood loss, severe burns, haemoglobin C, myelofibrosis and pernicious anaemia, some of which corresponds to rounded fragments of red cells.
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Caption: FIGURE 1: Peripheral blood smear showing polychromatophilia, numerous microspherocytes, and erythroblasts, some of which are dysplastic; schizocytes, Heinz bodies, and "bite cells" were not seen (Giemsa stain).
Peripheral smear revealed microcytic hypochromic anemia with polychromatophils, microspherocytes, and relative neutrophilia.
The RBC autoantibodies that result in a predominately extravascular hemolysis can cause spherocytosis, predominately composed of microspherocytes with a diameter of 5 iM or less (Figure, A).
1: Blood smear with microspherocytes and schisto- cytes (Giemsa stain).
Diagnoses were based on low-level hemoglobin, fragmented red cells, microspherocytes, polychromasia, macrocytosis, nucleated red cells on peripheral blood smear, elevated reticulocytes, and positive direct Coombs test (IgG+C3).
One patient went into acute renal failure with serum creatinine of 10.64 mg/dl and her peripheral blood smear showed red cell fragments and microspherocytes (Fig.
Examination of the peripheral blood film reveals a marked decrease in platelets, polychromic RBCs, and RBC fragmentation with microspherocytes, schistocytes, and keratocytes characteristic of microangiopathic hemolytic anemias.
Table 1 Laboratory features of : hemolytic uremic syndrome Anemia -- often severe Moderate neutrophilia Fragmented RBCs, burr cells, and microspherocytes Reticulocytosis Thrombocytopenia Hemoglobinemia Low haptoglobin Mildly elevated bilirubin Elevated urea nitrogen and creatinine Hemoglobinuria with RBCs, WBCs, and casts
[13] In ABO HDFN, microspherocytes were frequently prominent in blood films and red cell osmotic fragility was almost always above normal limits for upto 2-3 weeks after birth.
Peripheral smear showed large number of microspherocytes, microcytic hypochromic cells, target cells and occasional red cells with basophilic stippling (Figure 1).
Examination of a well-prepared peripheral blood film from a patient with HS reveals many characteristic microspherocytes, which appear as very deeply stained red cells with decreased diameters and without central pallor.
Examination of the peripheral blood smear revealed microspherocytes, polychromasia, and a few nucleated red blood cells.