(3) The above-mentioned problems could be overcome using microspheres
as multiple-unit dosage forms.
Target: Boston Scientific/portfolio of drug-loadable microsphere
and bland embolic bead products
This is because the prepared gel microsphere
is a kind of polymer composite microsphere
that has water absorption capability; thus, in the short soaking time, the water absorption ratio of the profile control agent increases gradually.
Caption: Figure 3: Drawing of aberrant microsphere
deposition in the stomach (reproduced with permission of the publisher, Frontiers in Oncology ).
There are many polymerization methods for preparing PS microspheres
, such as precipitation polymerization, seed polymerization, microemulsion, and dispersion polymerization.
To overcome the disadvantages of the polymeric microsphere
, a novel core-shell microsphere
is developed as the next-generation profile control agent [26-29], which has a core-shell double-layered structure.
The plugging effect of the DCA microsphere
was evaluated using three layers of the heterogeneous artificial core.
The control group received vehicle (0.9% NaCl: 5% Cremophor; p.o.) and experimental groups received usnic acid (UA, 2000, 300, and 50 mg/kg; p.o.), poly-[epsilon]-caprolactone microsphere
polymers containing usnic acid (UA-micro, 2000 mg/kg; p.o.), or indomethacin (10 mg/kg; p.o.).
Nouryon is the leading producer of expandable microspheres
. The company recently announced that it would invest in a new world-scale Expancel plant in the US, subject to final board approval.
Preparation of Imprinted Microspheres
Key statement: Self-sealing tire sealants are provided which contain fragments and/or residues of expanded solids, where the solids are selected from the group containing expandable graphite and microspheres
. In some aspects, the microspheres
include at least isobutane and/or isopentane as blowing agents.
Poly(lactic-co-glycolic acid) (PLGA) microspheres
(particle size < 10 [micro]m) were chosen as model particles due to their poor flow properties.