microsome


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to microsome: microsomal enzymes

microsome

 [mi´kro-sōm]
any of the vesicular fragments of endoplasmic reticulum produced during disruption and centrifugation of cells. adj., adj microso´mal.

mi·cro·some

(mī'krō-sōm),
One of the small spheric vesicles derived from the endoplasmic reticulum after disruption of cells and ultracentrifugation.
[micro- + G. sōma, body]

microsome

/mi·cro·some/ (mi´krah-sōm) any of the vesicular fragments of endoplasmic reticulum formed after disruption and centrifugation of cells.microso´mal

microsome

[mī′krəsōm]
a fragment of endoplasmic reticulum associated with ribosomes, found in cells that have been homogenized and ultracentrifuged.

microsome

Any of a heterogeneous group of variably sized and shaped, closed lipoprotein-rich vesicles, which are formed from ruptured endoplasmic reticulum and large polyribosomes when a cell is ultracentrifuged at 100,000 g for 60 minutes.

mi·cro·some

(mī'krō-sōm)
One of the small spheric vesicles derived from the endoplasmic reticulum after disruption of cells and ultracentrifugation.
[micro- + G. sōma, body]

microsome

see MICROSOMAL FRACTION.

microsome

any of the vesicular fragments of endoplasmic reticulum produced during disruption and centrifugation of cells.
Mentioned in ?
References in periodicals archive ?
The carbon monoxide-binding protein of liver microsomes.
Effect of Inorganic Mercury on Drug Metabolizing Enzymes of Promethazine-Pretreated and Phenobarbitone-Pretreated Male Rabbit
450] contents were expressed as [eta]mol cytochrome/mg microsomal protein, glutathione S-transeferase activity was expressed as units/mg protein, NADPH cytochrome C-reductase activity was expressed as [eta]mol cytochrome C-reductase/mg protein/min, amidopyrine N-demethylase in brain microsomes was expressed as [micro]mol/min x kg brain sample, aniline-4-hydroxylase was expressed as [micro]mol/min/mg protein, and thiobarbituric acid reactive substances (TBARS) were expressed as [micro]mol TBARS/g tissue.
Zinc and omega-3 mediates normalization of hepatic and cerebral cytochrome [P.sub.450s] in lindane-treated male rats
KEY WORDS: BDE-47, BDE metabolites, CYP2B6, human liver microsomes, hydroxylated metabolites, PBDE metabolism.
Biotransformation of BDE-47 to potentially toxic metabolites is predominantly mediated by human CYP2B6
Inhibition of deiodinase activity by TBMEHP in rat liver microsomes.
Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2-ethylhexyl) tetrabromophthalate (TBPH), a novel brominated flame retardant present in indoor dust
This plate-incorporation version of the Salmonellal mammalian microsome mutagenicity assay became a standard that is still in use today.
The Salmonella mutagenicity assay: the stethoscope of genetic toxicology for the 21st Century
InVitroCYP is the first product for the ADME-Tox market that delivers microsome products specifically for metabolic or inhibition studies without compromising P450 values, and without the time and cost of custom blending.
Celsis In Vitro Technologies Introduces New Assay-Specific Human Liver Microsomes
To verify the direct inhibitive effect of CO on CYP2E1 activity, rat hepatic microsomes were isolated by ultracentrifuge and incubated with ruthenium-containing CO releasing molecular (tricarbonyldichlororuthenium dimmer, CORM-2) which has been confirmed to possess the effects similar to CO administration as a gas.
Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity via depleting heme pool and releasing CO
Liver microsomes were prepared through ultracentrifugation which was developed in our laboratory (Li et al.
In vivo effect of Schisandrin B on cytochrome P450 enzyme activity
In case of pesticides, comparative in vitro metabolism studies using microsomes or intact cell systems of relevant experimental animals and human materials are a regulatory data requirement (EC, 2013) to determine the relevance of the toxicological animal data and to guide in the interpretation of findings and in further definition of the testing strategy.
Non-Animal Approaches for Toxicokinetics in Risk Evaluations of Food Chemicals
Microsomes were prepared from pooled lung or OM tissues of male, 2-month-old Cyp2abfgs-null, CYP2A13-humanized, or CYP2A13/2F1-humanized mice.
Human CYP2A13 and CYP2F1 mediate naphthalene toxicity in the lung and nasal mucosa of CYP2A13/2F1-humanized mice
13) have reported that ritonavir was similarly biotransformed by microsomes containing expressed CYP 3A4 or CYP 3A5 isoenzymes, whereas indinavir was metabolized more by CYP 3A4 than by CYP 3A5.
The Role of Cytochrome P450 3A5 Enzyme on the Metabolism of Tacrolimus in Rats
A study describing testosterone metabolism in vitro using fresh and frozen pigskin as well as human skin microsomes was published in 2014.
The metabolism of skin and how to test it

Medical browser ?
Full browser ?